Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension
2021; SAGE Publishing; Volume: 12; Issue: 1 Linguagem: Inglês
10.1002/pul2.12015
ISSN2045-8940
AutoresAline C. Oliveira, Tao Yang, Jing Li, Ravindra K. Sharma, Marianthi K. Karas, Andrew J. Bryant, Annette D. de Kloet, Eric G. Krause, Bina Joe, Elaine M. Richards, Mohan K. Raizada,
Tópico(s)Renin-Angiotensin System Studies
ResumoRecent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin-converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.
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