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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

2004; Elsevier BV; Volume: 14; Issue: 3 Linguagem: Inglês

10.1016/j.bmcl.2003.10.067

1464-3405

Laval Chan, Sanjoy Das, T. Jagadeeswar Reddy, Carl Poisson, Mélanie Proulx, Oswy Z. Pereira, Marc Courchesne, Caroline Roy, Wuyi Wang, Arshad Siddiqui, Constantin G. Yannopoulos, Nghe Nguyen‐Ba, Denis Labrecque, Richard C. Bethell, Martine Hamel, Philippe Courtemanche-Asselin, Lucille L’Heureux, Maud David, Olivier Nicolas, Stéphanie Brunette, Darius Bilimoria, Jean Bédard,

Hepatitis B Virus Studies

The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in Huh-7 cells.