Portal de Periódicos da CAPES

Neonatal seizures

2007; Wiley; Volume: 62; Issue: 2 Linguagem: Inglês

10.1002/ana.21167

1531-8249

Faye S. Silverstein, Frances E. Jensen,

Neonatal Respiratory Health Research

Abstract In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies have limited efficacy. Although the treatment of neonatal seizures has not significantly changed in the past several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This review includes an overview of current approaches to the diagnosis and treatment of neonatal seizures, identifies some of the critical factors that have limited progress, and highlights recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment. Ann Neurol 2007