SARS-CoV-2 infections in children: Understanding diverse outcomes
2022; Cell Press; Volume: 55; Issue: 2 Linguagem: Inglês
10.1016/j.immuni.2022.01.014
ISSN1097-4180
Autores Tópico(s)Kawasaki Disease and Coronary Complications
ResumoSARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but the reasons for this are not fully understood. More efficient local tissue responses, better thymic function, and cross-reactive immunity have all been proposed to explain this. In rare cases of children and young people, but very rarely in adults, post-infectious hyperinflammatory syndromes can develop and be serious. Here, I will discuss our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people.
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