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Zika-Associated Birth Defects Reported in Pregnancies with Laboratory Evidence of Confirmed or Possible Zika Virus Infection — U.S. Zika Pregnancy and Infant Registry, December 1, 2015–March 31, 2018

2022; Centers for Disease Control and Prevention; Volume: 71; Issue: 3 Linguagem: Inglês

10.15585/mmwr.mm7103a1

1545-861X

Nicole M. Roth, Megan R. Reynolds, Elizabeth Lewis, Kate R. Woodworth, Shana Godfred‐Cato, Augustina Delaney, Amanda Akosa, Miguel Valencia‐Prado, Maura K. Lash, Amanda L. Elmore, Peter H. Langlois, Salma Khuwaja, Aifili Tufa, Esther M. Ellis, Eirini Nestoridi, Caleb Lyu, Nicole D. Longcore, Monika Piccardi, Leah Lind, Sharon S. Starr, Loletha Johnson, Shea Elizabeth Browne, Michael Gosciminski, Paz E. Velasco, Fern Johnson-Clarke, Autumn Locklear, Mary Chan, Jane Fornoff, Karrie‐Ann Toews, Julius Tonzel, Natalie S. Marzec, Shelby Hale, Amy Nance, Teri’ Willabus, Dianna Contreras, Sowmya N. Adibhatla, Lisa Iguchi, Emily Potts, Elizabeth Schiffman, Katherine Lolley, Brandi Stricklin, Elizabeth Ludwig, Helentina Garstang, Meghan Marx, Emily Ferrell, Camille Moreno-Gorrin, Kimberly Signs, Paul A. Romitti, Vinita Leedom, Brennan Martin, Louisa Castrodale, Amie Cook, Carolyn Fredette, Lindsay Denson, Laura Cronquist, John F. Nahabedian, Neha Shinde, Kara D. Polen, Suzanne M. Gilboa, Stacey W. Martin, Janet D. Cragan, Dana Meaney‐Delman, Margaret A. Honein, Van T. Tong, Cynthia A. Moore,

Global Maternal and Child Health

Zika virus infection during pregnancy can cause serious birth defects of the brain and eyes, including intracranial calcifications, cerebral or cortical atrophy, chorioretinal abnormalities, and optic nerve abnormalities (1,2). The frequency of these Zika-associated brain and eye defects, based on data from the U.S. Zika Pregnancy and Infant Registry (USZPIR), has been previously reported in aggregate (3,4). This report describes the frequency of individual Zika-associated brain and eye defects among infants from pregnancies with laboratory evidence of confirmed or possible Zika virus infection. Among 6,799 live-born infants in USZPIR born during December 1, 2015-March 31, 2018, 4.6% had any Zika-associated birth defect; in a subgroup of pregnancies with a positive nucleic acid amplification test (NAAT) for Zika virus infection, the percentage was 6.1% of live-born infants. The brain and eye defects most frequently reported included microcephaly, corpus callosum abnormalities, intracranial calcification, abnormal cortical gyral patterns, ventriculomegaly, cerebral or cortical atrophy, chorioretinal abnormalities, and optic nerve abnormalities. Among infants with any Zika-associated birth defect, one third had more than one defect reported. Certain brain and eye defects in an infant might prompt suspicion of prenatal Zika virus infection. These findings can help target surveillance efforts to the most common brain and eye defects associated with Zika virus infection during pregnancy should a Zika virus outbreak reemerge, and might provide a signal to the reemergence of Zika virus, particularly in geographic regions without ongoing comprehensive Zika virus surveillance.