Tertiary lymphoid structures in cancer
2022; American Association for the Advancement of Science; Volume: 375; Issue: 6576 Linguagem: Inglês
10.1126/science.abf9419
ISSN1095-9203
AutoresTon N. Schumacher, Daniela S. Thommen,
Tópico(s)Immunotherapy and Immune Responses
ResumoEctopic lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are formed in numerous cancer types, and, with few exceptions, their presence is associated with superior prognosis and response to immunotherapy. In spite of their presumed importance, the triggers that lead to TLS formation in cancer tissue and the contribution of these structures to intratumoral immune responses remain incompletely understood. Here, we discuss the present knowledge on TLSs in cancer, focusing on (i) the drivers of TLS formation, (ii) the function and contribution of TLSs to the antitumor immune response, and (iii) the potential of TLSs as therapeutic targets in human cancers.
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