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Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis

2022; Elsevier BV; Volume: 372; Linguagem: Inglês

10.1016/j.cellimm.2021.104476

1090-2163

Allysson Cramer, Izabela Galvão, Nathália Venturini de Sá, Paulo Gaio, Natália Fernanda de Melo Oliveira, Mariana Rates Gonzaga Santos, Gabriel Henrique Campolina-Silva, Bruno Vinícius Santos Valiate, Fernanda Rezende Souza, Geovanni Dantas Cassali, Mauro Martins Teixeira, Flávio A. Amaral, Fabiana S. Machado,

NF-κB Signaling Pathways

Rheumatoid arthritis(RA) is a debilitating chronic inflammatory disease. Suppressors of Cytokine Signaling(SOCS) proteins regulate homeostasis and pathogenesis in several diseases. The intersection between RA pathophysiology and SOCS2 is unclear. Herein, we investigated the roles of SOCS2 during the development of an experimental antigen-induced arthritis(AIA). In wild type mice, joint SOCS2 expression was reduced during AIA development. At the peak of inflammation, SOCS2-/- mice presented with reduced numbers of infiltrated cells in their joints. At the late phase of AIA, however, exhibited increased adhesion/infiltration of neutrophils, macrophages, CD4+-T cells, CD4+CD8+-T cells, and CD4-CD8--T cells associated with elevated IL-17 and IFN-γ levels, joint damage, proteoglycan loss, and nociception. SOCS2 deficiency resulted in lower numbers of apoptotic neutrophils and reduced efferocytosis. The present study demonstrated the vital role of SOCS2 during the development and resolution of an experimental RA model. Hence, this protein may be a novel therapeutic target for this disorder.