Produção Nacional
Revisado por pares
Klebsiella-induced infections in domestic species: a case-series study in 697 animals (1997–2019)
2022; Springer Nature; Volume: 53; Issue: 1 Linguagem: Inglês
10.1007/s42770-021-00667-0
ISSN1678-4405
AutoresMárcio Garcia Ribeiro, Amanda Bonalume Cordeiro de Morais, Ana Carolina Alves, Carmen Alicia Daza Bolaños, Carolina Lechinski de Paula, Fábio Vinícius Ramos Portilho, Geraldo de Nardi, Gustavo Henrique Batista Lara, Lorrayne de Souza Araújo Martins, Lucieny Sierra Moraes, Rafaela Mastrangelo Risseti, Simony Trevizan Guerra, Thaís Spessotto Bello, Amanda Keller Siqueira, Amanda Bezerra Bertolini, Carolina Aparecida Rodrigues, Natália Rodrigues Paschoal, Beatriz Oliveira de Almeida, Fernando José Paganini Listoni, Luísa Fernanda García Sánchez, Antônio Carlos Paes,
Tópico(s)Enterobacteriaceae and Cronobacter Research
ResumoKlebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997-2019). The isolates were obtained from different clinical disorders from dogs (n = 393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n = 22), sheep (n = 5), goats (n = 2), and buffalo (n = 1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 = 12.2%), reproductive (85/697 = 12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 = 16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 = 74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62 = 40.3%), and trimethoprim/sulfamethoxazole (100/252 = 39.7), and multidrug resistance to ≥ 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and ~ 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern.
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