Ceramide kinase‐like protein promotes cutaneous squamous cell carcinoma
2021; Oxford University Press; Volume: 185; Issue: 1 Linguagem: Português
10.1111/bjd.20442
ISSN1365-2133
Tópico(s)Vascular Tumors and Angiosarcomas
ResumoBritish Journal of DermatologyVolume 185, Issue 1 p. e4-e4 Plain Language Summary Ceramide kinase-like protein promotes cutaneous squamous cell carcinoma First published: 02 July 2021 https://doi.org/10.1111/bjd.20442AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Linked Article: Meyer et al. Br J Dermatol 2021; 185:147–152. Ceramide kinase-like protein (CERKL) was originally described in retinal tissue in the eye. It has been shown to protect cells from oxidative stress, which is a process that kills cells; and mutations (faults) in CERKL cause an inherited disease called retinitis pigmentosa that leads to loss of vision. We set out to investigate CERKL in normal skin and in a type of skin cancer called cutaneous squamous cell carcinoma (cSCC). CERKL levels were low in normal skin but significantly increased in cSCC and also in actinic keratoses (areas of sun-damaged skin that sometimes can develop into skin cancer). Because of their fast metabolism, cancer cells have high levels of oxidative stress. CERKL appears to enable these cSCC cells to survive, because when we inactivated CERKL, the cSCC cells died. In conclusion, these findings suggest that CERKL may be important in disease progression in cSCC. Since CERKL is not expressed in normal skin cells, further investigation of CERKL could lead to novel strategies for prevention and treatment of cSCC. Volume185, Issue1July 2021Pages e4-e4 RelatedInformation
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