Treatment of Severe Japanese Encephalitis Complicated With Hashimoto’s Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report
2022; Frontiers Media; Volume: 12; Linguagem: Inglês
10.3389/fimmu.2021.807937
ISSN1664-3224
AutoresQiuling Zang, Yating Wang, Junshuang Guo, Liyang Long, Shuyu Zhang, Can Cui, D. Song, Boguang Yu, Fenlan Tang, Junfang Teng, Wang Miao,
Tópico(s)Infectious Encephalopathies and Encephalitis
ResumoA severely comatose female patient was diagnosed with Japanese encephalitis (JE). Her condition was complicated by Hashimoto’s thyroiditis (HT) and Guillain-Barré syndrome (GBS). After antiviral, glucocorticoid, and immunoglobulin treatment, the patient’s consciousness was restored, and she could breathe spontaneously. Following this, new-onset, primarily demyelinating GBS developed, which progressed to demyelination combined with axonal injury. The patient was switched to protein A immunoadsorption (PAIA) therapy, and her Hughes score decreased rapidly, from 4 to 1 after 6 months. This patient is the first to receive PAIA combined with an antiviral-glucocorticoid-immunoglobulin regimen to treat encephalitis, meningitis, HT, and GBS caused by JE infection, thereby reflecting the importance of clinical application of PAIA in the treatment of immunological complications of JE.
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