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Clindamycin Hydrochloride

1981; Elsevier BV; Linguagem: Inglês

10.1016/s0099-5428(08)60639-5

2163-5846

Leo W. Brown, William F. Beyer,

Antimicrobial Resistance in Staphylococcus

Clindamycin hydrochloride monohydrate is a white or practically white crystalline powder. It is odorless or has a faint mercaptan-like odor and a bitter taste. This chapter describes the physical properties, synthesis, drug metabolites, antibacterial activity, and methods of analysis of clindamycin hydrochloride. A typical mineral oil-mull spectrum of clindamycin hydrochloride monohydrate is presented in the chapter. Anhydrous clindamycin hydrochloride is hygroscopic; consequently, different crystal forms have been observed due to the degree of hydration. Solvation with ethanol or acetone is also possible, producing variation in the infrared spectrum. Nuclear magnetic resonance (NMR) is used to study the structure of lincomycin, its degradation products, and some analogs including clindamycin (7-chloro-7-deoxy-lincomycin). The NMR spectrum of lincomycin is found to be complex, containing many superimposed multiplets that are difficult to factor. Mass spectrometry is also used as a technique for structural determination of lincomycin, its degradation products, and analogs including clindamycin. Clindamycin has essentially the same fragmentation pattern as lincomycin.