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Epidemiology of dengue in Argentina: Antibodies seroprevalence in blood donors and circulating serotypes

2022; Elsevier BV; Volume: 147; Linguagem: Inglês

10.1016/j.jcv.2022.105078

1873-5967

Diego Flichman, Matías J. Pereson, Patricia Baré, Sonia L. Espíndola, Graciela Mabel Carballo, Andrés Albrecht, Felicitas Agote, Adriana Alter, Sonia Bartoli, Sebastián Blanco, Jorgelina L. Blejer, Marcelo Borda, Néstor Bouzon, Luis Carrizo, Lucrecia Etcheverry, Roberto Fernandez, Maria Reyes‐Mantilla, Sandra Gallego, Romina Hahn, Silvana Gisela Luna, Gabriela Marranzino, Joaquín Suarez Romanazzi, Ariel Rossi, Antonia Troffe, Chang-Chi Lin, Alfredo P. Martínez, Gabriel García, Federico A. Di Lello,

Vibrio bacteria research studies

Currently, dengue virus (DENV) infection is a world public health concern. In recent decades, three major outbreaks and a substantial growth of DENV infection prevalence have been observed in Argentina. However, there is a paucity of data on DENV epidemiology in this country. To estimate DENV antibodies seroprevalence and determine the circulating serotypes in a population-based study. Anti-DENV IgG antibodies were determined in 1,530 prospectively collected samples from blood donors throughout the country (April 2020 to April 2021). DENV serotyping was performed in 251 retrospectively analyzed samples (2016-2020). Overall, anti-DENV IgG was detected in 220 (14.4%) blood donors. Seroprevalence was significantly higher in men (17.3%) than in women (11.3%), p <0.001. A higher seroprevalence was observed in the Northeast (24.0%), compared to the Center (12.9%) and Northwest (10.8%) regions, (p <0.001). Prevalence of DENV serotypes was 79.3% (n=199) for DENV-1, 0.8% (n=2) for DENV-2, and 19.9% (n=50) for DENV-4. DENV serotypes were unevenly distributed in samples from different outbreaks and regions. This study provides new insights and updated data on the epidemiology of dengue in Argentina. The registered antibody seroprevalence is among the lowest one among Latin-American countries, raising cost-benefit objections with regards to massive vaccination policies. However, a high proportion of more than one circulating serotype should not be overlooked, as it is a warning of severe dengue possible increase in future Argentine outbreaks, which warrants close monitoring. • This study provides new insights on dengue (DENV) epidemiology in argentina. • Anti-DENV IgG was detected in 220/1530 (14.4%) blood donors in argentina. • Seroprevalence was significantly higher in men (17.3%) than in women (11.3%). • Prevalence of DENV serotypes was 79.3% for DENV-1 and 19.9% for DENV-4.