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BIBTEX RIS

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

2022; eLife Sciences Publications Ltd; Volume: 11; Linguagem: Inglês

10.7554/elife.70382

ISSN

2050-084X

Autores

Michael Chong, Pedrum Mohammadi‐Shemirani, Nicolas Perrot, Walter Nelson, Robert W. Morton, Sukrit Narula, Ricky Lali, Irfan Khan, Mohammad Daud Khan, Conor Judge, Tafadzwa Machipisa, Nathan Cawte, Martin O’Donnell, Marie Pigeyre, Loubna Akhabir, Guillaume Paré,

Tópico(s)

Metabolomics and Mass Spectrometry Studies

Resumo

Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial (MT) function. The specific biological processes underpinning its regulation, and whether those processes are causative for disease, is an area of active investigation.

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