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In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats

2022; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 1 Linguagem: Inglês

10.3390/polym14010188

2073-4360

Fabrício Egídio Pandini, Fabíola Mayumi Miyauchi Kubo, Ana Maria de Guzzi Plepis, Virgínia da Conceição Amaro Martins, Marcelo Rodrigues da Cunha, Vinícius Rodrigues Silva, Vinícius Barroso Hirota, Everton Lopes, Marcos Antonio Menezes, André Antônio Pelegrine, Tiago Negrão de Andrade, Amilton Iatecola, Bruna da Cruz Britto, Victor Augusto Ramos Fernandes, Luís Felipe Orsi Gameiro, Ronny Rodrigues Correia, Marcelo Lucchesi Teixeira, Getúlio Duarte Júnior, Carlos Henrique Bertoni Reis, Eliana de Souza Bastos Mazuqueli Pereira, Daniela Vieira Buchaim, Karina Torres Pomini, Daniel De Bortoli Teixeira, Rogério Leone Buchaim, Edmir Américo Lourenço,

Bone Tissue Engineering Materials

The aim of the present study was to evaluate the use of collagen, elastin, or chitosan biomaterial for bone reconstruction in rats submitted or not to experimental alcoholism. Wistar male rats were divided into eight groups, submitted to chronic alcohol ingestion (G5 to G8) or not (G1 to G4). Nasal bone defects were filled with clot in animals of G1 and G5 and with collagen, elastin, and chitosan grafts in G2/G6, G3/G7, and G4/G8, respectively. Six weeks after, all specimens underwent radiographic, tomographic, and microscopic evaluations. Bone mineral density was lower in the defect area in alcoholic animals compared to the abstainer animals. Bone neoformation was greater in the abstainer groups receiving the elastin membrane and in abstainer and alcoholic rats receiving the chitosan membrane (15.78 ± 1.19, 27.81 ± 0.91, 47.29 ± 0.97, 42.69 ± 1.52, 13.81 ± 1.60, 18.59 ± 1.37, 16.54 ± 0.89, and 37.06 ± 1.17 in G1 to G8, respectively). In conclusion, osteogenesis and bone density were more expressive after the application of the elastin matrix in abstainer animals and of the chitosan matrix in both abstainer and alcoholic animals. Chronic alcohol ingestion resulted in lower bone formation and greater formation of fibrous connective tissue.