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Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

2022; BMJ; Volume: 71; Issue: 10 Linguagem: Inglês

10.1136/gutjnl-2021-324994

1468-3288

Carolina F. Ruivo, Nuno Bastos, Bárbara Adem, Inês A. Batista, Cecília Durães, Carlos A. Melo, Stéphanie A. Castaldo, Francisco Campos‐Laborie, Pedro Moutinho-Ribeiro, B Morão, Ana Rita Costa-Pinto, Soraia Silva, Hugo Osório, Sergio Ciordia, José Luís Costa, David W. Goodrich, Bruno Cavadas, Luı́sa Pereira, Tony Kouzarides, Guilherme Macedo, Rui Maio, Fátima Carneiro, Marília Cravo, Raghu Kalluri, José Carlos Machado, Sónia A. Melo,

Hippo pathway signaling and YAP/TAZ

Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.