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Isoprostanoids, Isofuranoids and Isoketals – From Synthesis to Lipidomics

2022; Wiley; Volume: 2022; Issue: 21 Linguagem: Inglês

10.1002/ejoc.202101523

1434-193X

Claire Vigor, Laurence Balas, Alexandre Guy, Valérie Bultel‐Poncé, Guillaume Réversat, Jean-Marie Klinkenberg, Thierry Durand, Camille Oger,

Eicosanoids and Hypertension Pharmacology

Abstract A huge diversity of oxygenated metabolites originated from polyunsaturated fatty acids (PUFAs) had been discovered. Radical cascades are involved in the biosynthesis of these metabolites, and the radical initiation can be performed either inside the active site of an enzyme in the extracellular medium, or in membrane on phospholipids. The development of convergent and flexible chemical strategies to prepare these compounds by organic chemists, along with the development of sophisticated mass spectrometry methods, has boosted the knowledge regarding PUFA metabolites. Also, isoprostanoids have emerged as indicators of oxidative stress in humans and their environment. This Review provides a brief overview on the chemical strategies and analytical methods achieved over the past thirty years.