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Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa

2022; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2022.01.12.22269148

Mary‐Ann Davies, Reshma Kassanjee, Petro Rousseau, Erna Morden, Leigh F. Johnson, Wesley Solomon, Marvin Hsiao, Hannah Hussey, Graeme Meintjes, Masudah Paleker, Theuns Jacobs, Peter Raubenheimer, Alexa Heekes, Pierre Dane, Jamy‐Lee Bam, Mariette Smith, Wolfgang Preiser, David Pienaar, Marc Mendelson, Jonathan Naudé, Neshaad Schreuder, Ayanda Trevor Mnguni, Susan Le Roux, Katie Murie, Hans Prozesky, Hassan Mahomed, Liezel Rossouw, Sean Wasserman, Deborah Maughan, Linda Boloko, Barry Smith, Jantjie Taljaard, Greg Symons, Ntobeko Ntusi, Arifa Parker, Nicole Wolter, Waasila Jassat, Cheryl Cohen, Richard Lessells, Robert J. Wilkinson, Juanita Arendse, Saadiq Kariem, Melvin Moodley, Krish Vallabhjee, Milani Wolmarans, Andrew Boulle,

Viral Infections and Outbreaks Research

We aimed to compare COVID-19 outcomes in the Omicron-driven fourth wave with prior waves in the Western Cape, the contribution of undiagnosed prior infection to differences in outcomes in a context of high seroprevalence due to prior infection, and whether protection against severe disease conferred by prior infection and/or vaccination was maintained.