Portal de Periódicos da CAPES

Chronodisruption and Ambulatory Circadian Monitoring in Cancer Patients: Beyond the Body Clock

2022; Springer Science+Business Media; Volume: 24; Issue: 2 Linguagem: Inglês

10.1007/s11912-021-01158-z

1534-6269

Pedro Pagán, María Torrente, Manuel Campos, Mariano Provencio, Juan Antonio Madrid, Fernando Franco, Beatriz Rodríguez Morilla, Blanca Cantos, Pedro Sousa, María José Martínez Madrid, J. Pimentão, María Ángeles Rol,

Sleep and related disorders

Circadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms' disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease.In recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications. This review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the state-of-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.