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SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review

2022; Multidisciplinary Digital Publishing Institute; Volume: 7; Issue: 1 Linguagem: Inglês

10.3390/tropicalmed7010009

2414-6366

Caterina Ledda, Claudio Costantino, Giuseppe Motta, Rosario Cunsolo, Patrizia Stracquadanio, Giuseppe Di Liberti, Helena C. Maltezou, Venerando Rapisarda,

Viral gastroenteritis research and epidemiology

The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used: "Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*". The research was carried out utilizing the following databases: SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ranging from 0.011 to 0.001 (per 100 individuals at risk). Our findings further support the published high effectiveness rates of mRNA vaccines in preventing SARS-CoV-2 infections among fully vaccinated HCP. Additional studies are needed to define the duration of the vaccine-induced protection among HCP.