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SARS-CoV-2 Evolution and Spike-Specific CD4+ T-Cell Response in Persistent COVID-19 with Severe HIV Immune Suppression

2022; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 1 Linguagem: Inglês

10.3390/microorganisms10010143

2076-2607

Hortensia Álvarez, Ezequiel Ruiz‐Mateos, Pedro Miguel Juiz-González, Joana Vitallé, Irene Viéitez, María del Carmen Vázquez-Friol, Isabel Torres‐Beceiro, Alberto Pérez‐Gómez, Pilar Gallego‐García, Nuria Estévez‐Gómez, Loretta De Chiara, Eva Poveda, David Posada, Josep M. Llibre,

Long-Term Effects of COVID-19

Intra-host evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported in cases with persistent coronavirus disease 2019 (COVID-19). In this study, we describe a severely immunosuppressed individual with HIV-1/SARS-CoV-2 coinfection with a long-term course of SARS-CoV-2 infection. A 28-year-old man was diagnosed with HIV-1 infection (CD4+ count: 3 cells/µL nd 563000 HIV-1 RNA copies/mL) and simultaneous