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2021; Wiley; Volume: 30; Issue: 9 Linguagem: Inglês
10.1002/pro.4163
ISSN1469-896X
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoProtein ScienceVolume 30, Issue 9 Cover ImageFree Access Cover Image First published: 19 August 2021 https://doi.org/10.1002/pro.4163AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Non-homologous end joining (NHEJ) as the primary conserved DNA double-strand break repair process in human cells. NHEJ, more like a multi-component, multifunctional engine, functions mechanistically for its coordinated movements, assembles, and regulation. Like the old car engine malfunctioning without a linchpin and flexible belt, the NHEJ efficiency arises from a flexible conformational control principle. The NHEJ components were matched on the SKODA 100 car engine built in 1973 in Czechoslovakia. See article by Hammel and Tainer, pp. 1735–1756. Volume30, Issue9September 2021 RelatedInformation
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