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Anticoagulation Prior to COVID-19 Infection Has No Impact on 6 Months Mortality: A Propensity Score–Matched Cohort Study

2022; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 2 Linguagem: Inglês

10.3390/jcm11020352

2077-0383

Marcin Protasiewicz, Konrad Reszka, Wojciech Kosowski, Barbara Adamik, Wojciech Bombała, Adrian Doroszko, Damian Gajecki, Jakub Gawryś, Maciej Guziński, Maria Jędrzejczyk, Krzysztof Kaliszewski, Katarzyna Kiliś–Pstrusińska, Bogusława Konopska, Agnieszka Kopeć, Krzysztof Kujawa, Anna Langner, Anna Larysz, Weronika Lis, Lilla Pawlik-Sobecka, Joanna Górka-Dynysiewicz, Marta Rosiek‐Biegus, Agnieszka Matera-Witkiewicz, Tomasz Matys, Michał Pomorski, Mateusz Sokolski, Janusz Sokołowski, Anna Tomasiewicz-Zapolska, Katarzyna Madziarska, Ewa A. Jankowska,

COVID-19 and healthcare impacts

The coronavirus disease 2019 (COVID-19) shows high incidence of thromboembolic events in humans. In the present study, we aimed to evaluate if anticoagulation prior to COVID-19 infection may impact clinical profile, as well as mortality rate among patients hospitalized with COVID-19. The study was based on retrospective analysis of medical records of patients with laboratory confirmed SARS-CoV-2 infection. After propensity score matching (PSM), a group of 236 patients receiving any anticoagulant treatment prior to COVID-19 infection (AT group) was compared to 236 patients without previous anticoagulation (no AT group). In 180 days, the observation we noted comparable mortality rate in AT and no AT groups (38.5% vs. 41.1%, p = 0.51). Similarly, we did not observe any statistically significant differences in admission in the intensive care unit (14.1% vs. 9.6%, p = 0.20), intubation and mechanical ventilation (15.0% vs. 11.6%, p = 0.38), catecholamines usage (14.3% vs. 13.8%, p = 0.86), and bleeding rate (6.3% vs. 8.9%, p = 0.37) in both groups. Our results suggest that antithrombotic treatment prior to COVID-19 infection is unlikely to be protective for morbidity and mortality in patients hospitalized with COVID-19.