Portal de Periódicos da CAPES

Orthogonalization of far-field detection in tapered optical fibers for depth-selective fiber photometry in brain tissue

2022; AIP Publishing; Volume: 7; Issue: 2 Linguagem: Inglês

10.1063/5.0073594

2378-0967

Marco Bianco, Marco Pisanello, Antonio Balena, Cinzia Montinaro, Filippo Pisano, Barbara Spagnolo, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello,

Advanced Fluorescence Microscopy Techniques

The field of implantable optical neural interfaces has recently enabled the interrogation of neural circuitry with both cell-type specificity and spatial resolution in sub-cortical structures of the mouse brain. This generated the need to integrate multiple optical channels within the same implantable device, motivating the requirement of multiplexing and demultiplexing techniques. In this article, we present an orthogonalization method of the far-field space to introduce mode-division demultiplexing for collecting fluorescence from the implantable tapered optical fibers. This is achieved by exploiting the correlation between the transversal wavevector