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Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors

2019; Elsevier BV; Volume: 6; Issue: 10 Linguagem: Inglês

10.1016/s2352-3026(19)30106-1

2451-9960

Stephen Kaptoge, Emanuele Di Angelantonio, Carmel Moore, Matthew R. Walker, Jane Armitage, Willem H. Ouwehand, David J. Roberts, John Danesh, Simon G. Thompson, Stephen Kaptoge, Emanuele Di Angelantonio, Carmel Moore, Matthew R. Walker, Jane Armitage, Willem H. Ouwehand, David J. Roberts, John Danesh, Simon G. Thompson, Jenny Donovan, Ian Ford, Rachel Henry, Beverley J. Hunt, Bridget le Huray, Susan Mehenny, Gail Miflin, Jane Green, Mike Stredder, Nicholas A. Watkins, Alan McDermott, Clive Ronaldson, Claire Thomson, Zoe Tolkien, Lorna M. Williamson, David Allan, Jennifer Sambrook, Tracey Hammerton, David Bruce, Fizzah Choudry, Cedric Ghvaert, Kirstie Jonston, Anne M. Kelly, Andrew King, Alfred Mo, Lizanne Page, Penny Richardson, Peter Senior, Yagnesh Umrania, Henna Wong, Brendan Burchell, John Gallacher, Gavin J. Murphy, Adrian C. Newland, Keith Wheatley, M. Greaves, Marc Turner, Tahir Aziz, Richard A. Brain, Christine Davies, Ruth Turner, Paula Wakeman, Alison Dent, Alan Wakeman, Ben Anthony, Desmond Bland, Willem H Parrondo, Helen Vincent, Candy Weatherill, Andrea Forsyth, Carol Butterfield, Tracey Wright, Karen Ellis, Kristie Johnston, Pat Poynton, Carolyn Brooks, Emma Martin, Lara Littler, Lindsay Williamson, D. W. Blair, Karen Ackerley, Lynn Woods, S. Stanley, G. Walsh, Gayle Franklin, Cheryl Howath, Sarah Sharpe, Deborah R. Smith, Lauren Botham, Caroline Williams, Claire L. Alexander, Gareth Sowerbutts, Diane Furnival, Michael Thake, Shilpa N. Patel, Carolyn Roost, Sandra Sowerby, Mary Joy Appleton, Eileen Bays, Geoff Bowyer, Steven G. Clarkson, Stuart Halson, Kate Holmes, Gareth Humphreys, Lee Parvin-Cooper, Jason Towler, Joanne Addy, Patrica Barrass, Louise Stennett, Susan Burton, Hannah Dingwell, Victoria Clarke, Maria Potton, Thomas Bolton, Michael Daynes, Stuart Halson, Sarah Spackman, Michael G. Walker, Abudu Momodu, James Fenton, Adam King, Omer Muhammad, N Oates, Tim Peakman, Christine Ryan, Kristian Spreckley, Craig Stubbins, Joanna G Williams, James R. Brannan, Cedric Mochon, Samantha Taylor, Kimberly Warren, Stephen Kaptoge, Emanuele Di Angelantonio, Jonathan Mant, Willem H. Ouwehand, Simon G. Thompson, John Danesh, David J. Roberts,

Organ Donation and Transplantation

The INTERVAL trial showed that, over a 2-year period, inter-donation intervals for whole blood donation can be safely reduced to meet blood shortages. We extended the INTERVAL trial for a further 2 years to evaluate the longer-term risks and benefits of varying inter-donation intervals, and to compare routine versus more intensive reminders to help donors keep appointments.