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Biomarkers Commonly Associated with Urticaria Severity Do Not Correlate With Angioedema Activity Scores

2022; Elsevier BV; Volume: 149; Issue: 2 Linguagem: Inglês

10.1016/j.jaci.2021.12.561

1097-6825

Marina Sabaté Brescó, Nuria Rodríguez‐Garijo, Julián Azofra, María Luisa Baeza Ochoa de Ocáriz, Carmen Díaz Donado, P Gaig, Mar Guilarte, Valeria Herrera-Lasso Regás, Moisés Labrador‐Horrillo, Anna Sala Cunill, Beatriz Veleiro, María Pilar Gil, Marta Ferrer,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Numerous blood biomarkers have been explored in the context of Urticaria Activity Score (UAS) but little is known about their association with angioedema, which is not represented in UAS but can be assessed through Angioedema Activity Score (AAS). The association of these biomarkers with angioedema would be of interest for patients with Chronic Histaminergic Angioedema (CHA), for whom only AAS can be obtained. Fifty-one patients with urticaria and angioedema (CSU-AE) and 61 patients with CHA where recruited in 6 hospitals across Spain. Demographic and clinical variables were collected, as well as patient-reported disease activity validated questionnaires (UAS-7 and AAS-7). Eosinophil and basophil cell count, C-reactive protein, D-dimer and total IgE results were collected. In the CSU-AE group, when studying UAS-7 in association with the selected biomarkers, a significant inverse correlation was observed with eosinophil cell count (p=0.0392). The other 4 parameters did not reach statistical significance, although a trend was observed for D-dimer and basophil cell count. AAS-7 did not show any statistically significant correlation with the selected biomarkers, neither in CSU-AE nor in CHA group. In our cohort, eosinophil cell count significantly correlates with UAS-7. Other biomarkers did not correlate with UAS-7, although a trend was observed for some. On the other hand, CHA patients are often studied in the context of CSU, however, biomarkers commonly associated with CSU severity do not seem to correlate with angioedema severity. Specific studies are required for CHA subjects, to address properly their clinical phenotype.