The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers
2022; American Association for the Advancement of Science; Volume: 7; Issue: 68 Linguagem: Inglês
10.1126/sciimmunol.abo2990
ISSN2470-9468
Autores Tópico(s)T-cell and B-cell Immunology
ResumoColon cancer–derived TRIB3 reduced CXCL10 transcription and impaired CD8 T cell homing into tumors; reduction of TRIB3 levels increased CD8 T cell infiltration and rendered tumors responsive to immune checkpoint blockade.
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