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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

2022; Elsevier BV; Volume: 16; Linguagem: Inglês

10.1016/j.bioactmat.2022.01.027

ISSN

2097-1192

Autores

Maurício Gonçalves da Costa Sousa, Gabriela Conceição de Almeida, Danilo César Martins Mota, Rosiane Andrade da Costa, Simoni Campos Dias, Samuel Nunes Limberger, Frank Ko, Li Ting Lin, Evan F. Haney, Hashem Etayash, Beverlie Baquir, Michael J. Trimble, Ya Shen, Zheng Su, Markus Haapasalo, Daniel Pletzer, Letícia Chaves de Souza, Gláucia Schuindt Teixeira, Renato Silva, Robert E. W. Hancock, Octávio Luiz Franco, Taia Maria Berto Rezende,

Tópico(s)

Oral microbiology and periodontitis research

Resumo

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis, Staphylococcus aureus and a multispecies oral biofilm, besides anti-inflammatory activities. The in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

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