Portal de Periódicos da CAPES

The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4

2017; Wiley; Volume: 24; Issue: S2 Linguagem: Inglês

10.1111/jvh.12760

1365-2893

Henry Lik‐Yuen Chan, C. J. Chen, Ogu Omede, Jehad Al Qamish, Khalid Al Naamani, Abate Bane, S. S. Tan, Marieta Simonova, I. Cardenas, Moutaz Derbala, Onur Akın, Richard Odame Phillips, Marwa Abdelmageed, Maheeba Abdulla, Danjuma Adda, A. Al Baqali, N. Al Dweik, K. Al Ejji, Imad Ghazzawi, S. Al Kaabi, M. Al Sadadi, Jameela Al Salman, M. AlBadri, Said A. Al‐Busafi, Hamad Eid Al‐Romaihi, William Ampofo, Krasimir Antonov, Chukwuma Anyaike, F. Arome, Sarah Blach, M. M. Borodo, S. Brandon, Bisi Bright, M. T. Butt, Ding‐Shinn Chen, Pei‐Jer Chen, Rong‐Nan Chien, Wan‐Long Chuang, Diego Cuellar, A. A. Elbardiny, Chris Estes, Elmoubasher Farag, James Fung, Ivane Gamkrelidze, V. Garcìa, J Genov, Z. Ghandour, M. Ghuloom, B. Gómez, J. Gunter, J. Habeeb, O. Hajelssedig, Waseem Hamoudi, Sayed Himatt, Irena Hrstić, Ching‐Chih Hu, Chung‐Feng Huang, Yee Tak Hui, Rohani Jahis, Deian Jelev, Anil K John, Kulpash Kaliaskarova, Yasser Kamel, Jia‐Horng Kao, Jawad Khamis, H. Khattabi, Ibtissam Khoudri, Aliya Konysbekova, Iskren Kotzev, Moon Sing Lai, Wenyu Lao, Jennifer E. Layden, M. H. Lee, Olufunmilayo Lesi, M. Li, Acy Lo, Ching Kong Loo, Boris Lukšić, Abderrahmane Maaroufi, Abraham O. Malu, Lyudmila Mateva, R Mitova, Rosmawati Mohamed, Miro Morović, K. Murphy, B. Mustapha, Alexander Nersesov, Evelyn Ngige, Richard Njouom, Oudou Njoya, Diana Nonković, Solomon Obekpa, Stephen Oguche, Eucharia Okolo, Casimir Omuemu, Pascale Ondoa, Ohene Opare‐Sem, Shirley Owusu‐Ofori, Yuriy Prokopenko, Homie Razavi, Devin Razavi‐Shearer, Kathryn Razavi‐Shearer, Berhane Redae, Tatjana Reic, Tobias Rinke de Wit, Cielo Ríos, Sarah Robbins Scott, Lewis R. Roberts, S. J. Sanad, Jonathan Schmelzer, Manik Sharma, Tung‐Hung Su, K. Sultan, К. Tchernev, O. T. Y. Tsang, Simon H. Y. Tsang, Christian Tzeuton, S. Ugoeze, Benjamin Uzochukwu, R. Vi, Adriana Vince, Hamid Wani, Vincent Wai‐Sun Wong, A. Workneh, R. Yacoub, Kakharman Yesmembetov, M. Youbi, Man‐Fung Yuen, H. Nde,

Hepatitis B Virus Studies

Summary Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman); however, HCV‐related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high‐treatment rate will contribute to a reduction in total cases and HCV‐related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV‐related morbidity and mortality.