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Potentially inappropriate prescribing of DOACs to people with mechanical heart valves: A federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY

2022; Elsevier BV; Volume: 211; Linguagem: Inglês

10.1016/j.thromres.2022.01.023

1879-2472

Louis Fisher, Victoria Speed, Helen J Curtis, Christopher T. Rentsch, Angel Wong, Anna Schultze, Jon Massey, Peter Inglesby, Caroline E Morton, Marion Wood, Alex J Walker, Jessica Morley, Amir Mehrkar, Seb Bacon, George Hickman, Chris Bates, Richard Croker, David Evans, Tom Ward, Jonathan Cockburn, Simon Davy, Krishnan Bhaskaran, Becky Smith, Elizabeth Williamson, William Hulme, Amelia Green, Rosalind M. Eggo, Harriet Forbes, John Tazare, John Parry, Frank Hester, Sam Harper, Jonathan Meadows, Shaun O’Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths, Aaron Fowles, Nasreen Parkes, Ian Douglas, Stephen Evans, Liam Smeeth, Brian MacKenna, Laurie A. Tomlinson, Ben Goldacre,

Acute Myocardial Infarction Research

NHS England issued guidance for anticoagulant services during the COVID-19 pandemic including advice on the safe switching of patients on warfarin to direct oral anticoagulants (DOACs), where appropriate [ [1] Clinical guide for the management of anticoagulant services during the coronavirus pandemic [Internet]NHS England. https://www.nice.org.uk/Media/Default/About/COVID-19/Specialty-guides/specialty-guide-anticoagulant-services-and-coronavirus.pdfDate: 2021 Google Scholar ]. As DOACs require less frequent blood testing, this supported the reduction of pressures being experienced by the NHS and the lowering of the risk of virus transmission. We have previously shown that this guidance was followed by increased switching of anticoagulants to DOACs [ [2] Curtis H.J. Walker A.J. Croker R. Mehrkar A. Morton C.E. MacKenna B. et al. OpenSAFELY: impact of national guidance on switching from warfarin to direct oral anticoagulants (DOACs) in early phase of COVID-19 pandemic in England. Openheart. 2021; (Nov 16)https://doi.org/10.1136/openhrt-2021-001784 Google Scholar ].