Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

COVID-19 and Lung Mast Cells: The Kallikrein–Kinin Activation Pathway

2022; Multidisciplinary Digital Publishing Institute; Volume: 23; Issue: 3 Linguagem: Inglês

10.3390/ijms23031714

ISSN

1661-6596

Autores

Seigo Nagashima, Anderson Azevedo Dutra, Mayara Pezzini Arantes, Rafaela Chiuco Zeni, Carolline Konzen Klein, Flávia Centenaro de Oliveira, Giulia Werner Piper, Isadora Drews Brenny, Marcos Roberto Curcio Pereira, Rebecca Benício Stocco, Ana Paula Camargo Martins, Eduardo Morais de Castro, Caroline Busatta Vaz de Paula, Andréa Novais Moreno-Amaral, Cleber Machado‐Souza, Cristina Pellegrino Baena, Lúcia de Noronha,

Tópico(s)

Adenosine and Purinergic Signaling

Resumo

Mast cells (MCs) have relevant participation in inflammatory and vascular hyperpermeability events, responsible for the action of the kallikrein-kinin system (KKS), that affect patients inflicted by the severe form of COVID-19. Given a higher number of activated MCs present in COVID-19 patients and their association with vascular hyperpermeability events, we investigated the factors that lead to the activation and degranulation of these cells and their harmful effects on the alveolar septum environment provided by the action of its mediators. Therefore, the pyroptotic processes throughout caspase-1 (CASP-1) and alarmin interleukin-33 (IL-33) secretion were investigated, along with the immunoexpression of angiotensin-converting enzyme 2 (ACE2), bradykinin receptor B1 (B1R) and bradykinin receptor B2 (B2R) on

Referência(s)