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Hydrogel-Based Fiber Biofabrication Techniques for Skeletal Muscle Tissue Engineering

2022; American Chemical Society; Volume: 8; Issue: 2 Linguagem: Inglês

10.1021/acsbiomaterials.1c01145

2373-9878

Marina Volpi, Alessia Paradiso, Marco Costantini, Wojciech Święszkowski,

Tissue Engineering and Regenerative Medicine

The functional capabilities of skeletal muscle are strongly correlated with its well-arranged microstructure, consisting of parallelly aligned myotubes. In case of extensive muscle loss, the endogenous regenerative capacity is hindered by scar tissue formation, which compromises the native muscle structure, ultimately leading to severe functional impairment. To address such an issue, skeletal muscle tissue engineering (SMTE) attempts to fabricate