Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip
2022; Frontiers Media; Volume: 10; Linguagem: Inglês
10.3389/fbioe.2022.764237
ISSN2296-4185
AutoresAnastasiia Mykuliak, Alma Yrjänäinen, Antti-Juhana Mäki, Arjen Gebraad, Ella Lampela, Minna Kääriäinen, Toni-Karri Pakarinen, Pasi Kallio, Susanna Miettinen, Hanna Vuorenpää,
Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoThe vasculature is an essential, physiological element in virtually all human tissues. Formation of perfusable vasculature is therefore crucial for reliable tissue modeling. Three-dimensional vascular networks can be formed through the co-culture of endothelial cells (ECs) with stromal cells embedded in hydrogel. Mesenchymal stem/stromal cells (MSCs) derived from bone marrow (BMSCs) and adipose tissue (ASCs) are an attractive choice as stromal cells due to their natural perivascular localization and ability to support formation of mature and stable microvessels
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