Immune response induced by radiation with high- and low-let under different oxygen level
2022; Elsevier BV; Volume: 121; Issue: 3 Linguagem: Inglês
10.1016/j.bpj.2021.11.1683
ISSN1542-0086
AutoresYiu-Hsin Chang, Devin Miles, P. Harter, Jogendra Singh Pawar, Chang‐Deng Hu, Keith M. Stantz,
Tópico(s)Viral Infections and Vectors
ResumoIFN-beta has been shown to play an important role in STING-pathway, leading to an anti-tumor immune response. Our lab has demonstrated that ionizing radiation can induce a dose-response of IFN-beta and its down-regulator TREX1 when exposed to X-ray (low-LET) and fast neutron (high-LET). Our hypothesis is that under hypoxia, IFN-beta production is suppressed and will be recovered by using high-LET particle beam. The purpose of this study is to investigate immune response under the influence of high- and low-LET and oxygen level.
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