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Scientific Opinion on the risks to public health related to the presence of chromium in food and drinking water

2014; Wiley; Volume: 12; Issue: 3 Linguagem: Inglês

10.2903/j.efsa.2014.3595

ISSN

1831-4732

Tópico(s)

Heavy metals in environment

Resumo

EFSA JournalVolume 12, Issue 3 3595 OpinionOpen Access Scientific Opinion on the risks to public health related to the presence of chromium in food and drinking water EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM)Search for more papers by this author EFSA Panel on Contaminants in the Food Chain (CONTAM), EFSA Panel on Contaminants in the Food Chain (CONTAM)Search for more papers by this author First published: 13 March 2014 https://doi.org/10.2903/j.efsa.2014.3595Citations: 53 Panel members: Diane Benford, Sandra Ceccatelli, Bruce Cottrill, Michael DiNovi, Eugenia Dogliotti, Lutz Edler, Peter Farmer, Peter Fürst, Laurentius (Ron) Hoogenboom, Helle Katrine Knutsen, Anne-Katrine Lundebye, Manfred Metzler, Carlo Stefano Nebbia, Michael O'Keeffe, Ivonne Rietjens, Dieter Schrenk, Vittorio Silano, Hendrik van Loveren, Christiane Vleminckx, and Pieter Wester Correspondence: [email protected] Acknowledgement: The Panel wishes to thank the members of the Working Group on chromium and nickel: Michael DiNovi, Eugenia Dogliotti, Alessandro Di Domenico, Lutz Edler, Thierry Guerin, Antonio Mutti, Ivonne Rietjens, and Christiane Vleminckx for the preparatory work on this scientific opinion and EFSA staff: Davide Arcella, Marco Binaglia, Bistra Benkova, Gina Cioacata, Jose Angel Gomez Ruiz, Natalie Thatcher and Eniko Varga for the support provided to this scientific opinion. Adoption date: 27 February 2014 Published date: 13 March 2014 Question number: EFSA-Q-2012-00379 On request from: Hellenic Food Authority AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract EFSA received a request from the Hellenic Food Authority for a scientific opinion on estimation of the risk to human health from the presence of chromium (Cr) in food, particularly in vegetables, and Cr(VI) in bottled water. The CONTAM Panel derived a TDI of 0.3 mg/kg b.w. per day for Cr(III) from the lowest NOAEL identified in an NTP chronic oral toxicity study in rats. Under the assumption that all chromium in food is Cr(III), the mean and 95th percentile dietary exposure across all age groups were well below the TDI and therefore does not raise concerns for public health. In the case of drinking water, the Panel considered all chromium in water as Cr(VI). For non-neoplastic effects the lowest BMDL10 for diffuse epithelial hyperplasia of duodenum in female mice and the lowest BMDL05 for haematotoxicity in male rats in a 2-year NTP study were selected as reference points. The MOEs indicate that for non-neoplastic effects the current exposure levels to Cr(VI) via drinking water are of no concern for public health. For neoplastic effects, the CONTAM Panel selected a lowest BMDL10 for combined adenomas and carcinomas of the mouse small intestine as the reference point. 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