Scientific Opinion on a request for a review of a scientific publication concerning the zoonotic potential of ovine scrapie prions
2015; Wiley; Volume: 13; Issue: 8 Linguagem: Inglês
10.2903/j.efsa.2015.4197
ISSN1831-4732
Tópico(s)Prion Diseases and Protein Misfolding
ResumoEFSA JournalVolume 13, Issue 8 4197 OpinionOpen Access Scientific Opinion on a request for a review of a scientific publication concerning the zoonotic potential of ovine scrapie prions EFSA Panel on Biological Hazards (BIOHAZ Panel), EFSA Panel on Biological Hazards (BIOHAZ Panel)Search for more papers by this author EFSA Panel on Biological Hazards (BIOHAZ Panel), EFSA Panel on Biological Hazards (BIOHAZ Panel)Search for more papers by this author First published: 05 August 2015 https://doi.org/10.2903/j.efsa.2015.4197Citations: 15 Panel members: Ana Allende, Declan Bolton, Marianne Chemaly, Robert Davies, Pablo Salvador Fernandez Escamez, Rosina Girones, Lieve Herman, Kostas Koutsoumanis, Roland Lindqvist, Birgit Nørrung, Antonia Ricci, Lucy Robertson, Giuseppe Ru, Moez Sanaa, Marion Simmons, Panagiotis Skandamis, Emma Snary, Niko Speybroeck, Benno Ter Kuile, John Threlfall, and Helene Wahlström. Correspondence: biohaz@efsa.europa.eu Acknowledgement: The Panel wishes to thank the members of the Working Group on Zoonotic potential scrapie: Christine Hoffmann Fast, Romolo Nonno, Giuseppe Ru, Marion Simmons, John Spiropoulos, and Robert Will for the preparatory work on this scientific output and the hearing expert: Olivier Andreoletti and EFSA staff members: Pietro Stella and Angel Ortiz Pelaez for the support provided to this scientific output. Adoption date: 9 July 2015 Published date: 5 August 2015 Question number: EFSA-Q-2015-00048 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The factors that modulate the transmissibility of Transmissible Spongiform Encephalopathies (TSE) and the approaches for the study of their zoonotic potential are reviewed. The paper ' Evidence for zoonotic potential of ovine scrapie prions' by Cassard et al. (2014) is scientifically appraised, focussing on the experimental design, the results and the conclusions. The paper provides evidence in a laboratory experiment that some Classical scrapie isolates can propagate in humanised transgenic mice and produce prions that on second passage are similar to those causing one form of sporadic Creutzfeldt-Jakob disease (sCJD). It is concluded that the results from the study raise the possibility that scrapie prions have the potential to be zoonotic, but do not provide evidence that transmission can or does take place under field conditions. The conclusions of the 2011 ECDC-EFSA ' Joint Scientific Opinion on any possible epidemiological or molecular association between TSEs in animals and humans' are reviewed in the light of the new scientific evidence available since its publication. This supports and strengthens the conclusions of that opinion with regard to the potential for some animal TSE to be zoonotic, but does not provide evidence of a causal link between Classical or Atypical scrapie and human TSE. Current evidence does not establish this link, and no consistent risk factors have been identified for sCJD. The possibility of scrapie-related public health risks from the consumption of ovine products cannot be assessed. Recommendations are formulated on further studies and data that are needed to investigate the zoonotic potential of animal TSE and to estimate the amount of infectivity from TSE-infected products sourced from small ruminants and entering the food chain in the European Union. References Ahmad A, Rao F and Aieshah S, 2014. Two cases of Creutzfeldt-Jakob Disease from an ongoing dementia registry in Pakistan. Journal of the Pakistan Medical Association, 64, 705– 707. Akesson CP, Press CM, Tranulis MA, Jeffrey M, Aleksandersen M, Landsverk T and Espenes A, 2012. Phenotypic characterization of cells participating in transport of prion protein aggregates across the intestinal mucosa of sheep. Prion, 6, 261– 275. Asante EA, Linehan JM, Desbruslais M, Joiner S, Gowland I, Wood AL, Welch J, Hill AF, Lloyd SE, Wadsworth JDF and Collinge J, 2002. BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. Embo Journal, 21, 6358– 6366. Atalay FO, Tolunay S, Ozgun G, Bekar A and Zarifoglu M, 2015. Creutzfeldt-Jakob disease: report of four cases and review of the literature. Turk patoloji dergisi, 31, 148– 152. Baker HF, Ridley RM and Wells GAH, 1993. Experimental transmission of BSE and scrapie to the common marmoset. Veterinary Record, 132, 403– 406. Barria MA, Balachandran A, Morita M, Kitamoto T, Barron R, Manson J, Knight R, Ironside JW and Head MW, 2014a. Molecular barriers to zoonotic transmission of prions. Emerging Infectious Diseases, 20, 88– 97. Barria MA, Gonzalez-Romero D and Soto C, 2012. Cyclic amplification of prion protein misfolding. In: Amyloid proteins: methods and protocols, second edition. Eds EM Sigurdsson, M Calero and M Gasset, Humana Press Inc., Totowa, 199– 212. Barria MA, Ironside JW and Head MW, 2014b. Exploring the zoonotic potential of animal prion diseases in vivo and in vitro approaches. Prion, 8, 85– 91. Barria MA, Mukherjee A, Gonzalez-Romero D, Morales R and Soto C, 2009. De novo generation of infectious prions in vitro produces a new disease phenotype. PLoS Pathogens, 5. Barria MA, Telling GC, Gambetti P, Mastrianni JA and Soto C, 2011. Generation of a new form of human PrPSc in vitro by interspecies transmission from cervid prions. Journal of Biological Chemistry, 286, 7490– 7495. Beck KE, Chaplin M, Stack M, Sallis RE, Simonini S, Lockey R and Spiropoulos J, 2010b. Lesion profiling at primary isolation in RIII mice is insufficient in distinguishing BSE from Classical scrapie. Brain Pathology, 20, 313– 322. Beck KE, Sallis RE, Lockey R, Simmons MM and Spiropoulos J, 2010a. Ovine PrP genotype is linked with lesion profile and immunohistochemistry patterns after primary transmission of Classical scrapie to wild-type mice. Journal of Neuropathology and Experimental Neurology, 69, 483– 497. Beck KE, Sallis RE, Lockey R, Vickery CM, Beringue V, Laude H, Holder TM, Thorne L, Terry LA, Tout AC, Jayasena D, Griffiths PC, Cawthraw S, Ellis R, Balkema-Buschmann A, Groschup MH, Simmons MM and Spiropoulos J, 2012b. Use of murine bioassay to resolve ovine Transmissible Spongiform Encephalopathy cases showing a bovine spongiform encephalopathy molecular profile. Brain Pathology, 22, 265– 279. Beck KE, Vickery CM, Lockey R, Holder T, Thorne L, Terry LA, Denyer M, Webb P, Simmons MM and Spiropoulos J, 2012a. The interpretation of disease phenotypes to identify TSE strains following murine bioassay: characterisation of Classical scrapie. Veterinary Research, 43, doi:10.1186/1297–9716- 1143– 1177. Begue C, Martinetto H, Schultz M, Rojas E, Romero C, D'Giano C, Sevlever G, Somoza M and Taratuto AL, 2011. Creutzfeldt-Jakob disease surveillance in Argentina, 1997–2008. Neuroepidemiology, 37, 193– 202. Benestad SL, Austbo L, Tranulis MA, Espenes A and Olsaker I, 2012. Healthy goats naturally devoid of prion protein. Veterinary Research, 43, doi: 10.1186/1297–9716- 43– 87. Beringue V, Andreoletti O, Le Dur A, Essalmani R, Vilotte JL, Lacroux C, Reine F, Herzog L, Biacabe AG, Baron T, Caramelli M, Casalone C and Laude H, 2007. A bovine prion acquires an epidemic bovine spongiform encephalopathy strain-like phenotype on interspecies transmission. Journal of Neuroscience, 27, 6965– 6971. Beringue V, Herzog L, Reine F, Le Dur A, Casalone C, Vilotte JL and Laude H, 2008a. Transmission of atypical bovine prions to mice transgenic for human prion protein. Emerging Infectious Diseases, 14, 1898– 1901. Beringue V, Le Dur A, Tixador P, Reine F, Lepourry L, Perret-Liaudet A, Haik S, Vilotte JL, Fontes M and Laude H, 2008b. Prominent and persistent extraneural infection in human PrP transgenic mice infected with variant CJD. Plos One, 3. Bessen RA, Kocisko DA, Raymond GJ, Nandan S, Lansbury PT and Caughey B, 1995. Nongenetic propagation of strain-specific properties of scrapie prion protein. Nature, 375, 698– 700. Bishop MT, Hart P, Aitchison L, Baybutt HN, Plinston C, Thomson V, Tuzi NL, Head MW, Ironside JW, Will RG and Manson JC, 2006. Predicting susceptibility and incubation time of human-to-human transmission of vCJD. Lancet Neurology, 5, 393– 398. Bishop MT, Will RG and Manson JC, 2010. Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties. Proceedings of the National Academy of Sciences of the United States of America, 107, 12005– 12010. Biswas A, Khandelwal N, Pandit A, Roy A, Guin DS, Gangopadhyay G and Senapati A, 2013. Case series of probable sporadic Creutzfeldt-Jakob disease from Eastern India. Annals of Indian Academy of Neurology, 16, 659– 663. Bons N, Mestre-Frances N, Belli P, Cathala F, Gajdusek DC and Brown P, 1999. Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents. Proceedings of the National Academy of Sciences of the United States of America, 96, 4046– 4051. Bossers A, Belt P, Raymond GJ, Caughey B, de Vries R and Smits MA, 1997. Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms. Proceedings of the National Academy of Sciences of the United States of America, 94, 4931– 4936. Bossers A, De Vries R and Smits MA, 2000. Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP. Journal of Virology, 74, 1407– 1414. Bouybayoune I, Mantovani S, Del Gallo F, Bertani I, Restelli E, Comerio L, Tapella L, Baracchi F, Fernandez-Borges N, Mangieri M, Bisighini C, Beznoussenko GV, Paladini A, Balducci C, Micotti E, Forloni G, Castilla J, Fiordaliso F, Tagliavini F, Imeri L and Chiesa R, 2015. Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease. PLoS Pathogens, 11, doi:10.1371/journal.ppat.1004796. Brandel JP, Peckeu L and Haik S, 2013. The French surveillance network of Creutzfeldt-Jakob disease. Epidemiological data in France and worldwide. Transfusion Clinique et Biologique, 20, 395– 397. Bratosiewicz-Wasik J, Smolen-Dzirba J, Watala C, Rozemuller AJ, Jansen C, Spliet W, Jansen GH, Wasik TJ and Liberski PP, 2012. Association of the PRNP regulatory region polymorphisms with the occurrence of sporadic Creutzfeldt-Jakob disease. Folia Neuropathologica, 50, 68– 73. Brown P, Gibbs CJ, Rodgersjohnson P, Asher DM, Sulima MP, Bacote A, Goldfarb LG and Gajdusek DC, 1994. Human Spongiform Encephalopathy - the national-institutes-of-health series of 300 cases of experimentally transmitted disease. Annals of Neurology, 35, 513– 529. Bruce M, 2002. Strain typing of human and animal TSEs. Proceedings of the International Conference on Transmissible Spongiform Encephalopathies or Prion Diseases, 15th to 18th September 2002, Edinburgh, Scotland, UK. Available at: http://www.blackwellpublishing.com/products/journals/suppmat/nan/nan477/NAN477sm.pdf. Bruce ME, 2003. TSE strain variation. British Medical Bulletin, 66, 99– 108. Bruce ME, Boyle A, Cousens S, McConnell I, Foster J, Goldmann W and Fraser H, 2002. Strain characterization of natural sheep scrapie and comparison with BSE. Journal of General Virology, 83, 695– 704. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, McCardle L, Chree A, Hope J, Birkett C, Cousens S, Fraser H and Bostock CJ, 1997. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature, 389, 498– 501. Bucalossi C, Cosseddu G, D'Agostino C, Di Bari MA, Chiappini B, Conte M, Rosone F, De Grossi L, Scavia G, Agrimi U, Nonno R and Vaccari G, 2011. Assessment of the genetic susceptibility of sheep to scrapie by protein misfolding cyclic amplification and comparison with experimental scrapie transmission studies. Journal of Virology, 85, 8386– 8392. Buschmann A and Groschup MH, 2005. Highly bovine spongiform encephalopathy-sensitive transgenic mice confirm the essential restriction of infectivity to the nervous system in clinically diseased cattle. Journal of Infectious Diseases, 192, 934– 942. Cartier L, Quiroz G, Leiva M and Vergara C, 2012. Clinical and pathologic identification of different forms of Creutzfeldt Jakob disease in Chile. Revista Medica de Chile, 140, 161– 168. Cassard H, Torres JM, Lacroux C, Douet JY, Benestad SL, Lantier F, Lugan S, Lantier I, Costes P, Aron N, Reine F, Herzog L, Espinosa JC, Beringue V and Andreoletti O, 2014. Evidence for zoonotic potential of ovine scrapie prions. Nature Communications, 5, 5821. Castilla J, Gonzalez-Romero D, Saa P, Morales R, De Castro J and Soto C, 2008b. Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious Prions. Cell, 134, 757– 768. Castilla J, Morales R, Saa P, Barria M, Gambetti P and Soto C, 2008a. Cell-free propagation of prion strains. Embo Journal, 27, 2557– 2566. Castilla J, Saa P, Hetz C and Soto C, 2005b. In vitro generation of infectious scrapie prions. Cell, 121, 195– 206. Castilla J, Saa P and Soto C, 2005a. Detection of prions in blood. Nature Medicine, 11, 982– 985. Caughey WS, Raymond LD, Horiuchi M and Caughey B, 1998. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proceedings of the National Academy of Sciences of the United States of America, 95, 12117– 12122. Chianini F, Fernandez-Borges N, Vidal E, Gibbard L, Pintadoe B, De Castro J, Priola SA, Hamilton S, Eaton SL, Finlayson J, Pang Y, Steele P, Reid HW, Dagleish MP and Castilla J, 2012. Rabbits are not resistant to prion infection. Proceedings of the National Academy of Sciences of the United States of America, 109, 5080– 5085. Collinge J, Sidle KCL, Meads J, Ironside J and Hill AF, 1996. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature, 383, 685– 690. Comoy E, 2010. Transmission studies in primates. Workshop on the epidemiology of human and animal TSEs. 30 April 2010, Torino, Italy. Comoy E, Durand V, Correia E, Balachandran A, Richt J, Beringue V, Torres JM, Brown P, Hills B and Deslys JP, 2011b. Zoonotic potential of CWD: Experimental transmissions to non-human primates. Prion, 5, 101. Comoy E, Durand V, Correia E, Freire S, Richt J, Greenlee J, Torres JM, Brown P, Hills B and Deslys JP, 2011a. Transmissibility of BSE-L and cattle-adapted TME prion strain to cynomolgus macaque. Prion, 5, 100. Comoy E, Richt J, Durand V, Freire S, Correia E, Hamir A, Ruchoux MM, Brown P and Deslys JP, 2009. Transmission of bovine-passaged TME prion strain to macaque. Proceedings of the Prion 2009 Conference. Thessaloniki, Greece, 23–25 September 2009, 46. Comoy EE, Casalone C, Lescoutra-Etchegaray N, Zanusso G, Freire S, Marce D, Auvre F, Ruchoux MM, Ferrari S, Monaco S, Sales N, Caramelli M, Leboulch P, Brown P, Lasmezas CI and Deslys JP, 2008. Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate. Plos One, 3. Comoy EE, Mikol J, Luccantoni-Freire S, Correia E, Lescoutra-Etchegaray N, Durand V, Dehen C, Andreoletti O, Casalone C, Richt JA, Greenlee JJ, Baron T, Benestad SL, Brown P and Deslys JP, 2015. Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports, 5, doi:10.1038/srep11573. Corda E, Beck KE, Sallis RE, Vickery CM, Denyer M, Webb PR, Bellworthy SJ, Spencer YI, Simmons MM and Spiropoulos J, 2012. The interpretation of disease phenotypes to identify TSE strains in mice: characterisation of BSE using PrPSc distribution patterns in the brain. Veterinary Research, 43, doi:10.1186/1297–9716- 1143– 1186. Davanipour Z, Alter M, Sobel E, Asher DM and Gajdusek DC, 1985. A case-control study of Creutzfeldt-Jakob disease - dietary risk-factors. American Journal of Epidemiology, 122, 443– 451. Davanipour Z, Sobel E, Ziogas A, Smoak C, Bohr T, Doram K and Liwnicz B, 2014. Dietary risk factors for sporadic Creutzfeldt-Jakob disease: a confirmatory case-control study. British Journal of Medicine and Medical Research, 4, 2388– 2417. De Pedro Cuesta J, Ruiz Tovar M, Ward H, Calero M, Smith A, Verduras CA, Pocchiari M, Turner ML, Forland F, Palm D and Will RG, 2012. Sensitivity to biases of case-control studies on medical procedures, particularly surgery and blood transfusion, and risk of Creutzfeldt-Jakob disease. Neuroepidemiology, 39, 1– 18. DebBurman SK, Raymond GJ, Caughey B and Lindquist S, 1997. Chaperone-supervised conversion of prion protein to its protease-resistant form. Proceedings of the National Academy of Sciences of the United States of America, 94, 13938– 13943. Demaimay R, Harper J, Gordon H, Weaver D, Chesebro B and Caughey B, 1998. Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation. Journal of Neurochemistry, 71, 2534– 2541. Detwiler LA and Baylis M, 2003. The epidemiology of scrapie. Revue Scientifique tt Technique-Office International des Epizooties, 22, 121– 143. Di Bari MA, Chianini F, Vaccari G, Esposito E, Conte M, Eaton SL, Hamilton S, Finlayson J, Steele PJ, Dagleish MP, Reid HW, Bruce M, Jeffrey M, Agrimi U and Nonno R, 2008. The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie. Journal of General Virology, 89, 2975– 2985. Diringer H, Beekes M, Baldauf E, Cassens S and Ozel M, 1996. Amyloidosis: The key to the epidemiology and pathogenesis of transmissible spongiform encephalopathies. In: Bovine Spongiform Encephalopathy-The BSE Dilemma. Ed CJ Gibbs, Springer, New York, US, 251– 270. Donaldson DS, Kobayashi A, Ohno H, Yagita H, Williams IR and Mabbott NA, 2012. M cell-depletion blocks oral prion disease pathogenesis. Mucosal Immunology, 5, 216– 225. EFSA (European Food Safety Authority), 2007. Opinion of the Scientific Panel on Biological hazards on a request from the European Commission on certain aspects related to the risk of Transmissible Spongiform Encephalopathies (TSEs) in ovine and caprine animals. The EFSA Journal 2007, 466, 1– 10. EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2011. Joint Scientific Opinion on any possible epidemiological or molecular association between TSEs in animals and humans. EFSA Journal 2011; 9 (1): 1945, 111 pp. doi:10.2903/j.efsa.2011.1945. EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2014. Scientific Opinion on the scrapie situation in the EU after 10 years of monitoring and control in sheep and goats. EFSA Journal 2014; 12 (7): 3781, 155 pp. doi:10.2903/j.efsa.2014.3781. Eiden M, Hoffmann C, Balkema-Buschmann A, Muller M, Baumgartner K and Groschup MH, 2010. Biochemical and immunohistochemical characterization of feline spongiform encephalopathy in a German captive cheetah. Journal of General Virology, 91, 2874– 2883. Eiden M, Soto EO, Mettenleiter TC and Groschup MH, 2011. Effects of polymorphisms in ovine and caprine prion protein alleles on cell-free conversion. Veterinary Research, 42, doi: 10.1186/1297–9716- 1142– 1130. Epstein V, Pointing S and Halfacre S, 2005. Atypical scrapie in the Falkland islands. Veterinary Record, 157, 667– 668. Fryer HR and McLean AR, 2011. There is no safe dose of prions. Plos One, 6. Gajdusek DC and Gibbs CJJ, 1972. Transmission of kuru from man to Rhesus monkey (Macaca Mulatta) 8.5 years after inoculation. Nature (London), 240, 351. Gambetti P, Puoti G and Zou WQ, 2011. Variably protease-sensitive prionopathy: a novel disease of the prion protein. Journal of Molecular Neuroscience, 45, 422– 424. Gao C, Shi Q, Tian C, Chen C, Han J, Zhou W, Zhang BY, Jiang HY, Zhang J and Dong XP, 2011. The epidemiological, clinical, and laboratory features of sporadic Creutzfeldt-Jakob disease patients in China: Surveillance data from 2006 to 2010. Plos One, 6. Gibbs CJJ, Gajdusek DC, Asher DM, Alpers MP, Beck E, Daniel PM and Matthews WB, 1968. Creutzfeldt-Jakob disease spongiform encephalopathy transmission to the chimpanzee human virus kuru. Science (Washington DC), 161, 388– 389. Gill ON, Spencer Y, Richard-Loendt A, Kelly C, Dabaghian R, Boyes L, Linehan J, Simmons M, Webb P, Bellerby P, Andrews N, Hilton DA, Ironside JW, Beck J, Poulter M, Mead S and Brandner S, 2013. Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. BMJ-British Medical Journal, 347. Goni F, Mathiason CK, Yim L, Wong KL, Hayes-Klug J, Nalls A, Peyser D, Estevez V, Denkers N, Xu JF, Osborn DA, Miller KV, Warren RJ, Brown DR, Chabalgoity JA, Hoover EA and Wisniewski T, 2015. Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease. Vaccine, 33, 726– 733. Goudsmit J, Morrow CH, Asher DM, Yanagihara RT, Masters CL, Gibbs CJ and Gajdusek DC, 1980. Evidence for and against the transmissibility of Alzheimer-disease. Neurology, 30, 945– 950. Green KM, Castilla J, Seward TS, Napier DL, Jewell JE, Soto C and Telling GC, 2008. Accelerated high fidelity prion amplification within and across prion species barriers. PLoS Pathogens, 4. Gretzschel A, Buschmann A, Eiden M, Ziegler U, Luhken G, Erhardt G and Groschup MH, 2005. Strain typing of German transmissible spongiform encephalopathies field cases in small ruminants by biochemical methods. Journal of Veterinary Medicine Series B-Infectious Diseases and Veterinary Public Health, 52, 55– 63. Griffiths PC, Spiropoulos J, Lockey R, Tout AC, Jayasena D, Plater JM, Chave A, Green RB, Simonini S, Thorne L, Dexter I, Balkema-Buschmann A, Groschup MH, Beringue V, Le Dur A, Laude H and Hope J, 2010. Characterization of Atypical scrapie cases from Great Britain in transgenic ovine PrP mice. Journal of General Virology, 91, 2132– 2138. Gruner L, Elsen JM, Khang JVT, Eychenne F, Caritez JC, Jacquiet P, Andreoletti O, Sarradin P, Cortet J, Richer N and Leroux H, 2004. Nematode parasites and scrapie: experiments in sheep and mice. Parasitology Research, 93, 493– 498. Gubbels S, Bacci S, Laursen H, Hogenhaven H, Cowan S, Molbak K and Christiansen M, 2012. Description and analysis of 12 years of surveillance for Creutzfeldt-Jakob disease in Denmark, 1997 to 2008. Eurosurveillance, 17, 23– 31. Gurel A, Gulcubuk A, Turan N, Helps CR and Yilmaz H, 2013. Scrapie cases in Northern Cyprus. Turkish Journal of Veterinary & Animal Sciences, 37, 311– 315. Hajjaj I and Kissani N, 2011. First case of presumed sporadic Creutzfeldt-Jakob disease in Marrakech, Morocco. Médecine tropicale: revue du Corps de santé colonial, 71, 289– 291. Harries-Jones R, Knight R, Will RG, Cousens S, Smith PG and Matthews WB, 1988. Creutzfeldt-Jakob disease in England and Wales, 1980–1984 - A case-control study of potential risk-factors. Journal of Neurology Neurosurgery and Psychiatry, 51, 1113– 1119. Head MW and Ironside JW, 2007. vCJD and the gut: implications for endoscopy. Gut, 56, 9– 11. Hennekens CH, Buring JE and Doll R, 1987. Epidemiology in medicine. 255, Ed SL Mayrent, Boston: Little, Brown. 246– 252. Herrmann LM and Caughey B, 1998. The importance of the disulfide bond in prion protein conversion. Neuroreport, 9, 2457– 2461. Hill AF, Desbruslais M, Joiner S, Sidle KCL, Gowland I, Collinge J, Doey LJ and Lantos P, 1997. The same prion strain causes vCJD and BSE. Nature, 389, 448– 450. Hill AF, Joiner S, Beck JA, Campbell TA, Dickinson A, Poulter M, Wadsworth JDF and Collinge J, 2006. Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations. Brain, 129, 676– 685. Holznagel E, Yutzy B, Kruip C, Bierke P, Schulz-Schaeffer W and Löwer J, 2015. Foodborne-transmitted prions from the brain of cows with Bovine Spongiform Encephalopathy ascend in afferent neurons to the simian central nervous system and spread to tonsils and spleen at a late stage of the incubation period. Journal of Infectious Diseases, pii: jiv232. Holznagel E, Yutzy B, Schulz-Schaeffer W, Hanschman KM, Stuke A, Hahmann U, Torner M, Coulibaly C, Hoffmann A, Hunsmann G and Lower J, 2010. Increase in CD230 (cellular prion protein) fluorescence on blood lymphocytes in bovine spongiform encephalopathy-infected nonhuman primates. Transfusion, 50, 452– 466. Holznagel E, Yutzy B, Schulz-Schaeffer W, Kruip C, Hahmann U, Bierke P, Torres JM, Kim YS, Thomzig A, Beekes M, Hunsmann G and Loewer J, 2013. Foodborne transmission of Bovine Spongiform Encephalopathy to nonhuman primates. Emerging Infectious Diseases, 19, 712– 720. Ironside JW, 1998. New-variant Creutzfeldt-Jakob disease. Neuropathology, 18, 131– 138. Ironside JW, 2012. Transmissible spongiform encephalopathies (prion diseases). In: Medical microbiology: a guide to microbial infections: pathogenesis, immunity, laboratory investigation and control. Ed. 18. Eds D Greenwood, R Slack, M Barer and W Irving, 607– 613. Jansen C, Parchi P, Capellari S, Ibrahim-Verbaas CA, Schuur M, Strammiello R, Corrado P, Bishop MT, Van Gool WA, Verbeek MM, Baas F, Van Saane W, Spliet WGM, Jansen GH, Van Duijn CM and Rozemuller AJM, 2012. Human prion diseases in the Netherlands (1998–2009): Clinical, genetic and molecular aspects. Plos One, 7. Jones M, Peden AH, Head MW and Ironside JW, 2011. The application of in vitro cell-free conversion systems to human prion diseases. Acta Neuropathologica, 121, 135– 143. Jones M, Wight D, Barron R, Jeffrey M, Manson J, Prowse C, Ironside JW and Head MW, 2009. Molecular model of prion transmission to humans. Emerging Infectious Diseases, 15, 2013– 2016. Kittelberger R, Chaplin MJ, Simmons MM, Ramirez-Villaescusa A, McIntyre L, MacDiarmid SC, Hannah MJ, Jenner J, Bueno R, Bayliss D, Black H, Pigott CJ and O'Keefe JS, 2010. Atypical scrapie/Nor98 in a sheep from New Zealand. Journal of Veterinary Diagnostic Investigation, 22, 863– 875. Klug G, Wand H, Simpson M, Boyd A, Law M, Masters CL, Matej R, Howley R, Farrell M, Breithaupt M, Zerr I, Van Duijn C, Ibrahim-Verbaas C, Mackenzie J, Will RG, Brandel JP, Alperovitch A, Budka H, Kovacs GG, Jansen GH, Coulthard M and Collins SJ, 2013a. Intensity of human prion disease surveillance predicts observed disease incidence. Journal of Neurology Neurosurgery and Psychiatry, 84, 1372– 1377. Klug GM, Boyd A, Zhao T, Stehmann C, Simpson M, McLean CA, Masters CL and Collins SJ, 2013. Surveillance for Creutzfeldt-Jakob disease in Australia: update to December 2012. Communicable Diseases Intelligence Quarterly Report, 37, E115– 120. Kobayashi A, Mizukoshi K, Iwasaki Y, Miyata H, Yoshida Y and Kitamoto T, 2011. Co-occurrence of Types 1 and 2 PrPres in sporadic Creutzfeldt-Jakob disease MM1. American Journal of Pathology, 178, 1309– 1315. Kocisko DA, Priola SA, Raymond GJ, Chesebro B, Lansbury PT and Caughey B, 1995. Species-specificity in the cell-free conversion of prion protein to protease-resistant forms - a model for the scrapie species barrier. Proceedings of the National Academy of Sciences of the United States of America, 92, 3923– 3927. Kojima G, Tatsuno BK, Inaba M, Velligas S, Masaki K and Liow KK, 2013. Creutzfeldt-Jakob disease: a case report and differential diagnoses. Hawai'i Journal of Medicine & Public Health : a Journal of Asia Pacific Medicine & Public Health, 72, 136– 139. Kong QZ, Huang SH, Zou WQ, Vanegas D, Wang ML, Wu D, Yuan J, Zheng MJ, Bai H, Deng HY, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG and Gambetti P, 2005. Chronic wasting disease of elk: Transmissibility to humans examined by transgenic mouse models. Journal of Neuroscience, 25, 7944– 7949. Kong QZ, Zheng MJ, Casalone C, Qing LT, Huang SH, Chakraborty B, Wang P, Chen FS, Cali I, Corona C, Martucci F, Iulini B, Acutis P, Wang L, Liang JJ, Wang ML, Li XY, Monaco S, Zanusso G, Zou WQ, Caramelli M and Gambetti P, 2008. Evaluation of the human transmission risk of an Atypical B
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