The Thiosemicarbazones
1982; Springer Science+Business Media; Linguagem: Inglês
10.1007/978-3-642-68487-6_5
ISSN1865-0325
Autores Tópico(s)Computational Drug Discovery Methods
ResumoThe thiosemicarbazones stand as milestones in the emerging era of the specific treatment of viral diseases. They were the first true antiviral substances to be synthesized; although a number of random events had to take place before their potential was realized. The thiosemicarbazones were the first compounds to be found active in virus-infected animals. They were also the focus of the first systematic studies on the relationship between chemical structure and antiviral activity. Furthermore, these compounds were the first to be effective in humans and placed in clinical medicine Finally, there are no other compounds known which appear able to block the genetic expression of such a wide variety of viruses.
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