Scientific Opinion on the substantiation of health claims related to soy isoflavones and protection of DNA, proteins and lipids from oxidative damage (ID 1286, 4245), maintenance of normal blood LDL cholesterol concentrations (ID 1135, 1704a, 3093a), reduction of vasomotor symptoms associated with menopause (ID 1654, 1704b, 2140, 3093b, 3154, 3590), maintenance of normal skin tonicity (ID 1704a), contribution to normal hair growth (ID 1704a, 4254), “cardiovascular health” (ID 3587), treatment …
2011; Wiley; Volume: 9; Issue: 7 Linguagem: Inglês
10.2903/j.efsa.2011.2264
ISSN1831-4732
Tópico(s)Nutrition, Genetics, and Disease
ResumoEFSA JournalVolume 9, Issue 7 2264 OpinionOpen Access Scientific Opinion on the substantiation of health claims related to soy isoflavones and protection of DNA, proteins and lipids from oxidative damage (ID 1286, 4245), maintenance of normal blood LDL cholesterol concentrations (ID 1135, 1704a, 3093a), reduction of vasomotor symptoms associated with menopause (ID 1654, 1704b, 2140, 3093b, 3154, 3590), maintenance of normal skin tonicity (ID 1704a), contribution to normal hair growth (ID 1704a, 4254), “cardiovascular health” (ID 3587), treatment of prostate cancer (ID 3588) and “upper respiratory tract” (ID 3589) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)Search for more papers by this author EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)Search for more papers by this author First published: 28 July 2011 https://doi.org/10.2903/j.efsa.2011.2264Citations: 16 Panel members: Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser-Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren and Hans Verhagen Correspondence: [email protected] Acknowledgement: The Panel wishes to thank the members of the Working Group on Claims for the preparatory work on this scientific opinion: Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Marina Heinonen, Hannu Korhonen, Martinus Løvik, Ambroise Martin, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Inge Tetens, Hendrik van Loveren and Hans Verhagen Adoption date: 30 June 2011 Published date: 28 July 2011 Question number: EFSA-Q-2008-05018, EFSA-Q-2008-05019, EFSA-Q-2008-1874, EFSA-Q-2008-2024, EFSA-Q-2008-2390, EFSA-Q-2008-2440, EFSA-Q-2008-2873, EFSA-Q-2008-3825, EFSA-Q-2008-3886, EFSA-Q-2008-4312, EFSA-Q-2008-4313, EFSA-Q-2008-4314, EFSA-Q-2008-4315, EFSA-Q-2008-4955, EFSA-Q-2008-4964 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Albert A, Altabre C, Baro F, Buendia E, Cabero A, Cancelo MJ, Castelo-Branco C, Chantre P, Duran M, Haya J, Imbert P, Julia D, Lanchares JL, Llaneza P, Manubens M, Minano A, Quereda F, Ribes C and Vazquez F, 2002. Efficacy and safety of a phytoestrogen preparation derived from Glycine max (L.) Merr in climacteric symptomatology: a multicentric, open, prospective and non-randomized trial. Phytomedicine, 9, 85– 92. Albertazzi P, Pansini F, Bonaccorsi G, Zanotti L, Forini E and De Aloysio D, 1998. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol, 91, 6– 11. Albertazzi P, Steel SA and Bottazzi M, 2005. Effect of pure genistein on bone markers and hot flushes. Climacteric, 8, 371– 379. Allen JK, Becker DM, Kwiterovich PO, Lindenstruth KA and Curtis C, 2007. Effect of soy protein-containing isoflavones on lipoproteins in postmenopausal women. Menopause, 14, 106– 114. Allison DB, Gadbury G, Schwartz LG, Murugesan R, Kraker JL, Heshka S, Fontaine KR and Heymsfield SB, 2003. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr, 57, 514– 522. Anderson JW, Fuller J, Patterson K, Blair R and Tabor A, 2007. Soy compared to casein meal replacement shakes with energy-restricted diets for obese women: randomized controlled trial. Metabolism: Clinical and Experimental, 56, 280– 288. Ashton E and Ball M, 2000. Effects of soy as tofu vs meat on lipoprotein concentrations. Eur J Clin Nutr, 54, 14– 19. Atteritano M, Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Mazzaferro S, D'Anna R, Cannata ML, Gaudio A, Frisina A, Frisina N, Corrado F, Cancellieri F, Lubrano C, Bonaiuto M, Adamo EB and Squadrito F, 2007. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study. Journal of Clinical Endocrinology and Metabolism, 92, 3068– 3075. Balk JL, Whiteside DA, Naus G, DeFerrari E and Roberts JM, 2002. A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium. J Soc Gynecol Investig, 9, 238– 242. Basaria S, Wisniewski A, Dupree K, Bruno T, Song MY, Yao F, Ojumu A, John M and Dobs AS, 2009. Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal women. J Endocrinol Invest, 32, 150– 155. Baum JA, Teng H, Erdman JW, Jr., Weigel RM, Klein BP, Persky VW, Freels S, Surya P, Bakhit RM, Ramos E, Shay NF and Potter SM, 1998. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am J Clin Nutr, 68, 545– 551. Brzezinski A, Adlercreutz H, Shaoul R, Rosier A, Shmueli A, Tanos V and Schenker JG, 1997. Short-term Effects of Phytoestrogen-rich Diet on Postmenopausal Women. Menopause, 4, 89– 94. Burke GL, Legault C, Anthony M, Bland DR, Morgan TM, Naughton MJ, Leggett K, Washburn SA and Vitolins MZ, 2003. Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study. Menopause, 10, 147– 153. Campagnoli C, Abba C, Ambroggio S, Peris C, Perona M and Sanseverino P, 2005. Polyunsaturated fatty acids (PUFAs) might reduce hot flushes: an indication from two controlled trials on soy isoflavones alone and with a PUFA supplement. Maturitas, 51, 127– 134. Campbell CG, Brown BD, Dufner D and Thorland WG, 2006. Effects of soy or milk protein during a high-fat feeding challenge on oxidative stress, inflammation, and lipids in healthy men. Lipids, 41, 257– 265. Caserta L, Caserta R, Torella M, Nappo C, De Lucia D and Panariello S, 2005. [The effects of phytoestrogen therapy on the endometrium in postmenopausal women]. Minerva Ginecol, 57, 551– 555. Cassidy A, Albertazzi P, Lise Nielsen I, Hall W, Williamson G, Tetens I, Atkins S, Cross H, Manios Y, Wolk A, Steiner C and Branca F, 2006. Critical review of health effects of soyabean phytooestrogens in post-menopausal women. Proceedings of the Nutrition Society, 65, 76– 92. Cheng G, Wilczek B, Warner M, Gustafsson JA and Landgren BM, 2007. Isoflavone treatment for acute menopausal symptoms. Menopause, 14, 468– 473. Chiechi LM, Secreto G, Vimercati A, Greco P, Venturelli E, Pansini F, Fanelli M, Loizzi P and Selvaggi L, 2002. The effects of a soy rich diet on serum lipids: the Menfis randomized trial. Maturitas, 41, 97– 104. Colacurci N, Zarcone R, Borrelli A, De Franciscis P, Fortunato N, Cirillo M and Fornaro F, 2004. Effects of soy isoflavones on menopausal neurovegetative symptoms. Minerva Ginecol, 56, 407– 412. Crisafulli A, Marini H, Bitto A, Altavilla D, Squadrito G, Romeo A, Adamo EB, Marini R, D'Anna R, Corrado F, Bartolone S, Frisina N and Squadrito F, 2004. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause, 11, 400– 404. Crouse JR, 3rd, Morgan T, Terry JG, Ellis J, Vitolins M and Burke GL, 1999. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med, 159, 2070– 2076. D'Anna R, Cannata ML, Atteritano M, Cancellieri F, Corrado F, Baviera G, Triolo O, Antico F, Gaudio A, Frisina N, Bitto A, Polito F, Minutoli L, Altavilla D, Marini H and Squadrito F, 2007. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study. Menopause, 14, 648– 655. Dalais FS, Rice GE, Wahlqvist ML, Grehan M, Murkies AL, Medley G, Ayton R and Strauss BJ, 1998. Effects of dietary phytoestrogens in postmenopausal women. Climacteric, 1, 124– 129. de Kleijn MJ, van der Schouw YT, Wilson PW, Grobbee DE and Jacques PF, 2002. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study. Journal of Nutrition, 132, 276– 282. Dent SB, Peterson CT, Brace LD, Swain JH, Reddy MB, Hanson KB, Robinson JG and Alekel DL, 2001. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. J Nutr, 131, 2280– 2287. DiSilvestro RA, Mattern C, Wood N and Devor ST, 2006. Soy protein intake by active young adult men raises plasma antioxidant capacity without altering plasma testosterone. Nutrition Research, 26, 92– 95. Drews K, Seremak-Mrozikiewicz A, Puk E, Kaluba-Skotarczak A, Malec M and Kazikowska A, 2007. [Efficacy of standardized isoflavones extract (Soyfem) (52–104 mg/24h) in moderate and medium-severe climacteric syndrome]. Ginekol Pol, 78, 307– 311. Duffy R, Wiseman H and File SE, 2003. Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharmacol Biochem Behav, 75, 721– 729. Engelman HM, Alekel DL, Hanson LN, Kanthasamy AG and Reddy MB, 2005. Blood lipid and oxidative stress responses to soy protein with isoflavones and phytic acid in postmenopausal women. Am J Clin Nutr, 81, 590– 596. Faure ED, Chantre P and Mares P, 2002. Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study. Menopause, 9, 329– 334. Ferretti G, Bacchetti T, Menanno F and Curatola G, 2004. Effect of genistein against copper-induced lipid peroxidation of human high density lipoproteins (HDL). Atherosclerosis, 172, 55– 61. Gallagher JC, Satpathy R, Rafferty K and Haynatzka V, 2004. The effect of soy protein isolate on bone metabolism. Menopause, 11, 290– 298. Gardner CD, Newell KA, Cherin R and Haskell WL, 2001. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr, 73, 728– 735. Gonzalez S, Jayagopal V, Kilpatrick ES, Chapman T and Atkin SL, 2007. Effects of isoflavone dietary supplementation on cardiovascular risk factors in type 2 diabetes. Diabetes Care, 30, 1871– 1873. Griffiths H, Moller L, Bartosz G, Bast A, Bertoni-Freddari C, Collins A, Cooke M, Coolen S, Haenen G, Hoberg A, Loft S, Lunec J, Olinski R, Parry J, Pompella A, Poulsen H, Verhagen H and Astley S, 2002. Biomarkers. Molecular Aspects of Medicine, 23, 101– 208. Han KK, Soares JM, Jr., Haidar MA, de Lima GR and Baracat EC, 2002. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol, 99, 389– 394. Hermansen K, Sondergaard M, Hoie L, Carstensen M and Brock B, 2001. Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects. Diabetes Care, 24, 228– 233. Hodgson JM, Puddey IB, Beilin LJ, Mori TA and Croft KD, 1998. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr, 128, 728– 732. Howes LG, Howes JB and Knight DC, 2006. Isoflavone therapy for menopausal flushes: a systematic review and meta-analysis. Maturitas, 55, 203– 211. Huntley AL and Ernst E, 2004. Soy for the treatment of perimenopausal symptoms-a systematic review. Maturitas, 47, 1– 9. Hwang J, Sevanian A, Hodis HN and Ursini F, 2000. Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid. Free Radical Biology and Medicine, 29, 79– 89. Imhof M, Gocan A and Schmidt M, 2008. Improvement of menopausal symptoms by soy isoflavones: a randomized double-blind study. Planta Med, 74. Jenkins DJ, Kendall CW, Vidgen E, Vuksan V, Jackson CJ, Augustin LS, Lee B, Garsetti M, Agarwal S, Rao AV, Cagampang GB and Fulgoni V, 3rd, 2000. Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein. Metabolism, 49, 1496– 1500. Jenkins DJ, Kendall CW, Jackson CJ, Connelly PW, Parker T, Faulkner D, Vidgen E, Cunnane SC, Leiter LA and Josse RG, 2002. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr, 76, 365– 372. Jou HJ, Ling PY and Wu SC, 2005. Comparison of 70 mg and 35 mg isoflavone soya supplement for menopause symptoms. Int J Gynaecol Obstet, 90, 159– 160. Jou HJ, Wu SC, Chang FW, Ling PY, Chu KS and Wu WH, 2008. Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones. Int J Gynaecol Obstet, 102, 44– 49. Kaari C, Haidar MA, Junior JM, Nunes MG, Quadros LG, Kemp C, Stavale JN and Baracat EC, 2006. Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study. Maturitas, 53, 49– 58. Khaodhiar L, Ricciotti HA, Li L, Pan W, Schickel M, Zhou J and Blackburn GL, 2008. Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women. Menopause, 15, 125– 132. Knight DC, Howes JB, Eden JA and Howes LG, 2001. Effects on menopausal symptoms and acceptability of isoflavone-containing soy powder dietary supplementation. Climacteric, 4, 13– 18. Kok L, Kreijkamp-Kaspers S, Grobbee DE, Lampe JW and van der Schouw YT, 2005. A randomized, placebo-controlled trial on the effects of soy protein containing isoflavones on quality of life in postmenopausal women. Menopause, 12, 56– 62. Kotsopoulos D, Dalais FS, Liang YL, McGrath BP and Teede HJ, 2000. The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women. Climacteric, 3, 161– 167. Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EH, Aleman A, Lampe JW and van der Schouw YT, 2004. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA, 292, 65– 74. Kronenberg F and Fugh-Berman A, 2002. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med, 137, 805– 813. Lapointe A, Couillard C and Lemieux S, 2006. Effects of dietary factors on oxidation of low-density lipoprotein particles. The Journal of Nutritional Biochemistry, 17, 645– 658. Lethaby AE, Marjoribanks J, Kronenberg F, Roberts H, Eden J and Brown J, 2007. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev, CD001395. Lewis JE, Nickell LA, Thompson LU, Szalai JP, Kiss A and Hilditch JR, 2006. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause, 13, 631– 642. Lichtenstein AH, Jalbert SM, Adlercreutz H, Goldin BR, Rasmussen H, Schaefer EJ and Ausman LM, 2002. Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler Thromb Vasc Biol, 22, 1852– 1858. Lissin LW, Oka R, Lakshmi S and Cooke JP, 2004. Isoflavones improve vascular reactivity in postmenopausal women with hypercholesterolemia. Vascular Medicine, 9, 26– 30. Ma DF, Qin LQ, Wang PY and Katoh R, 2008a. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials. Clinical Nutrition, 27, 57– 64. Ma DF, Qin LQ, Wang PY and Katoh R, 2008b. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. European Journal of Clinical Nutrition, 62, 155– 161. Ma Y, Chiriboga D, Olendzki BC, Nicolosi R, Merriam PA and Ockene IS, 2005. Effect of soy protein containing isoflavones on blood lipids in moderately hypercholesterolemic adults: a randomized controlled trial. Journal of the American College of Nutrition, 24, 275– 285. MacGregor CA, Canney PA, Patterson G, McDonald R and Paul J, 2005. A randomised double-blind controlled trial of oral soy supplements versus placebo for treatment of menopausal symptoms in patients with early breast cancer. Eur J Cancer, 41, 708– 714. Mackey R, Ekangaki A and Eden JA, 2000. The effects of soy protein in women and men with elevated plasma lipids. Biofactors, 12, 251– 257. Maesta N, Nahas EA, Nahas-Neto J, Orsatti FL, Fernandes CE, Traiman P and Burini RC, 2007. Effects of soy protein and resistance exercise on body composition and blood lipids in postmenopausal women. Maturitas, 56, 350– 358. McVeigh BL, Dillingham BL, Lampe JW and Duncan AM, 2006. Effect of soy protein varying in isoflavone content on serum lipids in healthy young men. Am J Clin Nutr, 83, 244– 251. Meinertz H, Nilausen K and Hilden J, 2002. Alcohol-extracted, but not intact, dietary soy protein lowers lipoprotein(a) markedly. Arterioscler Thromb Vasc Biol, 22, 312– 316. Merz-Demlow BE, Duncan AM, Wangen KE, Xu X, Carr TP, Phipps WR and Kurzer MS, 2000. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr, 71, 1462– 1469. Murkies AL, Lombard C, Strauss BJ, Wilcox G, Burger HG and Morton MS, 1995. Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat. Maturitas, 21, 189– 195. Nagata C, Takatsuka N, Kurisu Y and Shimizu H, 1998. Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. Journal of Nutrition, 128, 209– 213. Nagata C, Shimizu H, Takami R, Hayashi M, Takeda N and Yasuda K, 1999. Hot flushes and other menopausal symptoms in relation to soy product intake in Japanese women. Climacteric, 2, 6– 12. Nagata C, Takatsuka N, Kawakami N and Shimizu H, 2001. Soy product intake and hot flashes in Japanese women: results from a community-based prospective study. Am J Epidemiol, 153, 790– 793. Nahas EA, Nahas-Neto J, Orsatti FL, Carvalho EP, Oliveira ML and Dias R, 2007. Efficacy and safety of a soy isoflavone extract in postmenopausal women: a randomized, double-blind, and placebo-controlled study. Maturitas, 58, 249– 258. Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, Nicolaidis C, Walker M and Humphrey L, 2006. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA, 295, 2057– 2071. Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Owen A and Abbey M, 1997. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arteriosclerosis, Thrombosis, and Vascular Biology, 17, 3392– 3398. Nikander E, Kilkkinen A, Metsa-Heikkila M, Adlercreutz H, Pietinen P, Tiitinen A and Ylikorkala O, 2003. A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients. Obstet Gynecol, 101, 1213– 1220. Penotti M, Fabio E, Modena AB, Rinaldi M, Omodei U and Vigano P, 2003. Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril, 79, 1112– 1117. Petri Nahas E, Nahas Neto J, De Luca L, Traiman P, Pontes A and Dalben I, 2004. Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas, 48, 372– 380. Puska P, Korpelainen V, Hoie LH, Skovlund E, Lahti T and Smerud KT, 2002. Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial. Eur J Clin Nutr, 56, 352– 357. Quella SK, Loprinzi CL, Barton DL, Knost JA, Sloan JA, LaVasseur BI, Swan D, Krupp KR, Miller KD and Novotny PJ, 2000. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial. J Clin Oncol, 18, 1068– 1074. Ricciotti HA, Khaodhiar L and Blackburn GL, 2005. Daidzein-rich isoflavone-aglycones for menopausal symptoms. Int J Gynaecol Obstet, 89, 65– 66. Sagara M, Kanda T, M Nj, Teramoto T, Armitage L, Birt N, Birt C and Yamori Y, 2004. Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland. J Am Coll Nutr, 23, 85– 91. Sammartino A, Di Carlo C, Mandato VD, Bifulco G, Di Stefano M and Nappi C, 2003. Effects of genistein on the endometrium: ultrasonographic evaluation. Gynecol Endocrinol, 17, 45– 49. Scambia G, Mango D, Signorile PG, Anselmi Angeli RA, Palena C, Gallo D, Bombardelli E, Morazzoni P, Riva A and Mancuso S, 2000. Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause, 7, 105– 111. Scheiber MD, Liu JH, Subbiah MT, Rebar RW and Setchell KD, 2001. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause, 8, 384– 392. Secreto G, Chiechi LM, Amadori A, Miceli R, Venturelli E, Valerio T and Marubini E, 2004. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas, 47, 11– 20. Somekawa Y, Chiguchi M, Ishibashi T and Aso T, 2001. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstetrics and Gynecology, 97, 109– 115. St Germain A, Peterson CT, Robinson JG and Alekel DL, 2001. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause, 8, 17– 26. Steinberg FM, Guthrie NL, Villablanca AC, Kumar K and Murray MJ, 2003. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. American Journal of Clinical Nutrition, 78, 123– 130. Takatsuka N, Nagata C, Kurisu Y, Inaba S, Kawakami N and Shimizu H, 2000. Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. Prev Med, 31, 308– 314. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K and Watanabe S, 2007. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. American Journal of Clinical Nutrition, 85, 1148– 1156. Taku K, Umegaki K, Ishimi Y and Watanabe S, 2008. Effects of extracted soy isoflavones alone on blood total and LDL cholesterol: Meta-analysis of randomized controlled trials. Journal of Therapeutics and Clinical Risk Management, 4, 1097– 1103. Teede HJ, Dalais FS, Kotsopoulos D, Liang YL, Davis S and McGrath BP, 2001. Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab, 86, 3053– 3060. Teixeira SR, Potter SM, Weigel R, Hannum S, Erdman JW, Jr. and Hasler CM, 2000. Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am J Clin Nutr, 71, 1077– 1084. Tempfer CB, Bentz EK, Leodolter S, Tscherne G, Reuss F, Cross HS and Huber JC, 2007. Phytoestrogens in clinical practice: a review of the literature. Fertil Steril, 87, 1243– 1249. Tonstad S, Smerud K and Hoie L, 2002. A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects. Am J Clin Nutr, 76, 78– 84. Uesugi S, Watanabe S, Ishiwata N, Uehara M and Ouchi K, 2004. Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women. Biofactors, 22, 221– 228. Upmalis DH, Lobo R, Bradley L, Warren M, Cone FL and Lamia CA, 2000. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study. Menopause, 7, 236– 242. Urban D, Irwin W, Kirk M, Markiewicz MA, Myers R, Smith M, Weiss H, Grizzle WE and Barnes S, 2001. The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen. J Urol, 165, 294– 300. Van Patten CL, Olivotto IA, Chambers GK, Gelmon KA, Hislop TG, Templeton E, Wattie A and Prior JC, 2002. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol, 20, 1449– 1455. Verhoye E and Langlois M, 2009. Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk? Clinical Chemistry and Laboratory Medicine, 47, 128– 137. Vigna GB, Pansini F, Bonaccorsi G, Albertazzi P, Donega P, Zanotti L, De Aloysio D, Mollica G and Fellin R, 2000. Plasma lipoproteins in soy-treated postmenopausal women: a double-blind, placebo-controlled trial. Nutr Metab Cardiovasc Dis, 10, 315– 322. Wangen KE, Duncan AM, Xu X and Kurzer MS, 2001. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr, 73, 225– 231. Washburn S, Burke GL, Morgan T and Anthony M, 1999. Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause, 6, 7– 13. Welty FK, Lee KS, Lew NS, Nasca M and Zhou JR, 2007a. The association between soy nut consumption and decreased menopausal symptoms. J Womens Health (Larchmt), 16, 361– 369. Welty FK, Lee KS, Lew NS and Zhou JR, 2007b. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med, 167, 1060– 1067. West SG, Hilpert KF, Juturu V, Bordi PL, Lampe JW, Mousa SA and Kris-Etherton PM, 2005. Effects of including soy protein in a blood cholesterol-lowering diet on markers of cardiac risk in men and in postmenopausal women with and without hormone replacement therapy. Journal of Womens Health, 14, 253– 262. Wiseman H, O'Reilly JD, Adlercreutz H, Mallet AI, Bowey EA, Rowland IR and Sanders TA, 2000. Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. American Journal of Clinical Nutrition, 72, 395– 400. Wong WW, Smith EO, Stuff JE, Hachey DL, Heird WC and Pownell HJ, 1998. Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men. Am J Clin Nutr, 68, 1385S– 1389S. Yildirir A, Tokgozoglu SL, Oduncu T, Oto A, Haznedaroglu I, Akinci D, Koksal G, Sade E, Kirazli S and Kes S, 2001. Soy protein diet significantly improves endothelial function and lipid parameters. Clin Cardiol, 24, 711– 716. Zhan S and Ho SC, 2005. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr, 81, 397– 408. Zhuo XG, Melby MK and Watanabe S, 2004. Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. J Nutr, 134, 2395– 2400. Citing Literature Volume9, Issue7July 20112264 ReferencesRelatedInformation
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