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Predictive value of D-dimer in the clinical outcome of severe COVID19 patients: Are we giving it too much credit?

2022; SAGE Publishing; Volume: 28; Linguagem: Inglês

10.1177/10760296221079612

1938-2723

José Pedro Cidade, Luís Coelho, Vasco Costa, Rui Morais, Patrícia Moniz, L. L. MORAIS, Pedro Fidalgo, António Tralhão, Maria Carolina Paulino, David Nora, Bernardino Valério, Vítor Mendes, Camila Tapadinhas, Pedro Póvoa,

Sepsis Diagnosis and Treatment

COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality.To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality.Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups: (1) Lower-values group (D-dimer levels < 3-fold normal range value [NRV] [500ng/mL]), Intermediate-values group (D-dimer ≥3-fold and <10-fold NRV) and Higher-value group (≥10-fold NRV).118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables.In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients' survivability and should not be used as a surrogate of disease severity.