Staphylococcal Biofilms
2018; American Society for Microbiology; Volume: 6; Issue: 4 Linguagem: Inglês
10.1128/microbiolspec.gpp3-0023-2018
ISSN2165-0497
Autores Tópico(s)Antimicrobial Peptides and Activities
ResumoABSTRACT Staphylococci, with the leading species Staphylococcus aureus and Staphylococcus epidermidis , are the most frequent causes of infections on indwelling medical devices. The biofilm phenotype that those bacteria adopt during device-associated infection facilitates increased resistance to antibiotics and host immune defenses. This review presents and discusses the molecular mechanisms contributing to staphylococcal biofilm development and their in-vivo importance. Furthermore, it summarizes current strategies for the development of therapeutics against staphylococcal biofilm-associated infection.
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