Produção Nacional
Revisado por pares
Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case–Control Study
2022; Oxford University Press; Volume: 48; Issue: 5 Linguagem: Inglês
10.1093/schbul/sbac022
ISSN1745-1701
AutoresGiada Tripoli, Diego Quattrone, Laura Ferraro, Charlotte Gayer‐Anderson, Caterina La Cascia, Daniele La Barbera, Crocettarachele Sartorio, Fabio Seminerio, Victoria Rodríguez, Ilaria Tarricone, Domenico Berardi, Stéphane Jamain, Celso Arango, Andrea Tortelli, Pierre‐Michel Llorca, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miquel Bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Cristina Marta Del‐Ben, Paulo Rossi Menezes, E. van der Ven, Peter B. Jones, Hannah E. Jongsma, James B. Kirkbride, Sarah Tosato, Antonio Lasalvia, Alexander Richards, Michael O’Donovan, Bart P. F. Rutten, Jim van Os, Craig Morgan, Pak C. Sham, Marta Di Forti, Robin M. Murray, Graham K. Murray,
Tópico(s)Tryptophan and brain disorders
ResumoFacial Emotion Recognition is a key domain of social cognition associated with psychotic disorders as a candidate intermediate phenotype. In this study, we set out to investigate global and specific facial emotion recognition deficits in first-episode psychosis, and whether polygenic liability to psychotic disorders is associated with facial emotion recognition.828 First Episode Psychosis (FEP) patients and 1308 population-based controls completed assessments of the Degraded Facial Affect Recognition Task (DFAR) and a subsample of 524 FEP and 899 controls provided blood or saliva samples from which we extracted DNA, performed genotyping and computed polygenic risk scores for schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MD).A worse ability to globally recognize facial emotion expressions was found in patients compared with controls [B= -1.5 (0.6), 95% CI -2.7 to -0.3], with evidence for stronger effects on negative emotions (fear [B = -3.3 (1.1), 95% CI -5.3 to -1.2] and anger [B = -2.3 (1.1), 95% CI -4.6 to -0.1]) than on happiness [B = 0.3 (0.7), 95% CI -1 to 1.7]. Pooling all participants, and controlling for confounds including case/control status, facial anger recognition was associated significantly with Schizophrenia Polygenic Risk Score (SZ PRS) [B = -3.5 (1.7), 95% CI -6.9 to -0.2].Psychosis is associated with impaired recognition of fear and anger, and higher SZ PRS is associated with worse facial anger recognition. Our findings provide evidence that facial emotion recognition of anger might play a role as an intermediate phenotype for psychosis.
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