Membrane Fusion
1992; American Association for the Advancement of Science; Volume: 258; Issue: 5084 Linguagem: Inglês
10.1126/science.1439803
ISSN1095-9203
Autores Tópico(s)Bacteriophages and microbial interactions
ResumoCommon themes are emerging from the study of viral, cell-cell, intracellular, and liposome fusion. Viral and cellular membrane fusion events are mediated by fusion proteins or fusion machines. Viral fusion proteins share important characteristics, notably a fusion peptide within a transmembrane-anchored polypeptide chain. At least one protein involved in a cell-cell fusion reaction resembles viral fusion proteins. Components of intracellular fusion machines are utilized in multiple membrane trafficking events and are conserved through evolution. Fusion pores develop during viral and intracellular fusion events suggesting similar mechanisms for many, if not all, fusion events.
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