Antimitotic Substances
1968; Elsevier BV; Linguagem: Inglês
10.1016/s0074-7696(08)61398-4
ISSN2163-5854
Autores Tópico(s)Cancer-related Molecular Pathways
ResumoAntimitotic substances are tools which enable the cytologist to dissect the interrelated phases of the mitotic cycle. The words “antimitotic substance” can have only a very general significance and include every substance that lessens the number of mitoses in a cell population, whatever the mechanism of this reduction may be. The inhibiting effect theoretically can result from obstruction of the onset of prophase, from arrest of one of the mitotic stages, from inhibition of the mitotic apparatus, or, last, from faulty separation of the chromosomes. The action exercised on proliferation and mitosis, the strength and features of which are easily estimated, can be used as a test to study variations in cell permeability to numerous substances or modifications on a great many metabolisms. In fact, every change in permeability to an antimitotic agent is manifested in the end by a modification in strength of the exercised action; likewise, every impairment of the metabolism, the equilibrium of which is necessary to cell multiplication, is shown up as a visible, morphological effect on mitotic proliferation, rate, or characteristics. Thus, the study of antimitotic effects may constitute a technique suitable to various problems of general physiology.
Referência(s)