A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
2022; Springer Nature; Volume: 14; Issue: 3 Linguagem: Inglês
10.15252/emmm.202114552
ISSN1757-4684
AutoresLucía Zhu, Diana Retana, Pedro García‐Gómez, Laura Álvaro‐Espinosa, Neibla Priego, Mariam Masmudi‐Martín, Natalia Yebra, Lauritz Miarka, Elena Hernández‐Encinas, Carmen Blanco‐Aparicio, Sonia Martı́nez, Cecilia Sobrino, Nuria Ajenjo, María-Jesús Artiga, Eva Ortega‐Paino, Raúl Torres, Sandra Rodríguez, Riccardo Soffietti, Luca Bertero, Paola Cassoni, Tobias Weiß, Javier Muñoz, Juan Manuel Sepúlveda-Sánchez, P. González, Luis Jiménez‐Roldán, Luis Miguel Moreno-Gómez, Olga Esteban, Ángel Pérez‐Núñez, Aurelio Hernández‐Laín, Óscar Toldos, Yolanda Ruano, Lucía Alcázar, Guillermo Blasco, J.F. Alén, Eduardo Caleiras, Miguel Lafarga, Diego Megı́as, Osvaldo Graña‐Castro, Carolina Nör, Michael D. Taylor, Leonie S. Young, Damir Varešlija, Nicola Cosgrove, Fergus J. Couch, Lorena Cussó, Manuel Desco, Silvana Mourón, Miguel Quintela‐Fandino, Michael Weller, Joaquı́n Pastor, Manuel Valiente, Adolfo de la Lama‐Zaragoza, Lourdes Calero‐Felix, Concepcion Fiaño‐Valverde, Pedro David Delgado‐López, Antonio Montalvo‐Afonso, Mar Pascual‐Llorente, Ángela Díaz‐Piqueras, SH Nam‐Cha, C. López, Gerard Plans Ahicart, Elena Martínez‐Sáez, Santiago Ramón y Cajal, Pilar Nicolás,
Tópico(s)Histone Deacetylase Inhibitors Research
ResumoArticle17 February 2022Open Access Transparent process A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis Lucía Zhu Lucía Zhu Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - original draft, Writing - review & editing Search for more papers by this author Diana Retana Diana Retana Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Validation, Investigation, Visualization, Methodology Search for more papers by this author Pedro García-Gómez Pedro García-Gómez orcid.org/0000-0003-0694-3942 Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Laura Álvaro-Espinosa Laura Álvaro-Espinosa Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Investigation, Methodology Search for more papers by this author Neibla Priego Neibla Priego Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Investigation, Methodology Search for more papers by this author Mariam Masmudi-Martín Mariam Masmudi-Martín Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Investigation, Methodology Search for more papers by this author Natalia Yebra Natalia Yebra Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Visualization, Methodology Search for more papers by this author Lauritz Miarka Lauritz Miarka Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Data curation, Formal analysis, Validation, Writing - review & editing Search for more papers by this author Elena Hernández-Encinas Elena Hernández-Encinas Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Formal analysis, Methodology Search for more papers by this author Carmen Blanco-Aparicio Carmen Blanco-Aparicio Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Resources, Formal analysis, Validation, Investigation, Methodology Search for more papers by this author Sonia Martínez Sonia Martínez orcid.org/0000-0003-2230-7794 Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Formal analysis, Validation, Investigation, Visualization, Methodology Search for more papers by this author Cecilia Sobrino Cecilia Sobrino Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Investigation, Methodology Search for more papers by this author Nuria Ajenjo Nuria Ajenjo Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Resources, Project administration Search for more papers by this author Maria-Jesus Artiga Maria-Jesus Artiga orcid.org/0000-0003-0436-8497 Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Supervision, Project administration Search for more papers by this author Eva Ortega-Paino Eva Ortega-Paino Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Resources, Supervision, Project administration Search for more papers by this author Raúl Torres-Ruiz Raúl Torres-Ruiz orcid.org/0000-0001-9606-0398 Molecular Cytogenetics Unit, CNIO, Madrid, Spain Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Madrid, Spain Search for more papers by this author Sandra Rodríguez-Perales Sandra Rodríguez-Perales Molecular Cytogenetics Unit, CNIO, Madrid, Spain Contribution: Methodology Search for more papers by this author RENACER RENACER The list of additional RENACER members and their affiliations appears at the end of this article. Search for more papers by this author Riccardo Soffietti Riccardo Soffietti Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy Contribution: Resources, Writing - review & editing Search for more papers by this author Luca Bertero Luca Bertero orcid.org/0000-0001-9887-7668 Department of Medical Sciences, University of Turin, Turin, Italy Contribution: Formal analysis, Validation, Methodology Search for more papers by this author Paola Cassoni Paola Cassoni Department of Medical Sciences, University of Turin, Turin, Italy Contribution: Resources, Supervision Search for more papers by this author Tobias Weiss Tobias Weiss orcid.org/0000-0002-5533-9429 Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland Contribution: Resources, Formal analysis, Validation, Investigation, Methodology, Writing - review & editing Search for more papers by this author Javier Muñoz Javier Muñoz orcid.org/0000-0003-3288-3496 Proteomics Unit, ProteoRedISCIII, CNIO, Madrid, Spain Contribution: Resources, Formal analysis, Validation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Juan Manuel Sepúlveda Juan Manuel Sepúlveda Neuro-Oncology Unit, Hospital Universitario 12 de Octubre, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Search for more papers by this author Pedro González-León Pedro González-León Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Resources, Investigation, Methodology Search for more papers by this author Luis Jiménez-Roldán Luis Jiménez-Roldán Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Department of Surgery, Universidad Complutense de Madrid, Madrid, Spain Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Resources, Formal analysis, Investigation, Methodology Search for more papers by this author Luis Miguel Moreno Luis Miguel Moreno orcid.org/0000-0003-4963-7064 Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Search for more papers by this author Olga Esteban Olga Esteban Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Resources, Validation, Investigation, Methodology Search for more papers by this author Ángel Pérez-Núñez Ángel Pérez-Núñez orcid.org/0000-0002-2391-6586 Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Department of Surgery, Universidad Complutense de Madrid, Madrid, Spain Neuro-Oncology Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Resources, Formal analysis, Supervision, Investigation, Visualization, Writing - review & editing Search for more papers by this author Aurelio Hernández-Laín Aurelio Hernández-Laín Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Data curation, Supervision, Validation, Investigation, Methodology, Writing - review & editing Search for more papers by this author Oscar Toldos Oscar Toldos Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Validation, Methodology Search for more papers by this author Yolanda Ruano Yolanda Ruano Pathology Department, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Universidad Francisco de Vitoria, Madrid, Spain Contribution: Methodology Search for more papers by this author Lucía Alcázar Lucía Alcázar Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain Search for more papers by this author Guillermo Blasco Guillermo Blasco Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain Search for more papers by this author José Fernández-Alén José Fernández-Alén Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Supervision, Project administration Search for more papers by this author Eduardo Caleiras Eduardo Caleiras Histopathology Unit, CNIO, Madrid, Spain Contribution: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology Search for more papers by this author Miguel Lafarga Miguel Lafarga orcid.org/0000-0003-3402-1152 Department of Anatomy and Cell Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of Cantabria-IDIVAL, Santander, Spain Contribution: Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Diego Megías Diego Megías Confocal Microscopy Unit, CNIO, Madrid, Spain Contribution: Validation, Investigation, Visualization, Methodology Search for more papers by this author Osvaldo Graña-Castro Osvaldo Graña-Castro Bioinformatics Unit, CNIO, Madrid, Spain Search for more papers by this author Carolina Nör Carolina Nör Developmental and Stem Cell Biology Program and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada Contribution: Resources, Supervision, Validation, Investigation, Methodology Search for more papers by this author Michael D Taylor Michael D Taylor Developmental and Stem Cell Biology Program and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada Search for more papers by this author Leonie S Young Leonie S Young Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland Contribution: Resources, Data curation, Supervision, Methodology Search for more papers by this author Damir Varešlija Damir Varešlija orcid.org/0000-0003-1000-0357 Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland Contribution: Data curation, Validation, Investigation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Nicola Cosgrove Nicola Cosgrove Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland Contribution: Resources, Data curation, Methodology, Writing - review & editing Search for more papers by this author Fergus J Couch Fergus J Couch Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA Contribution: Resources, Data curation Search for more papers by this author Lorena Cussó Lorena Cussó Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain Unidad de Imagen Avanzada, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Contribution: Formal analysis, Methodology Search for more papers by this author Manuel Desco Manuel Desco Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain Unidad de Imagen Avanzada, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Contribution: Formal analysis, Supervision, Visualization, Methodology Search for more papers by this author Silvana Mouron Silvana Mouron Breast Cancer Clinical Research Unit, CNIO, Madrid, Spain Contribution: Data curation, Formal analysis, Visualization, Methodology, Writing - review & editing Search for more papers by this author Miguel Quintela-Fandino Miguel Quintela-Fandino Breast Cancer Clinical Research Unit, CNIO, Madrid, Spain Search for more papers by this author Michael Weller Michael Weller Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland Contribution: Supervision, Validation, Methodology Search for more papers by this author Joaquín Pastor Joaquín Pastor Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Resources, Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology Search for more papers by this author Manuel Valiente Corresponding Author Manuel Valiente [email protected] orcid.org/0000-0002-0647-7542 Brain Metastasis Group, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing - original draft, Project administration, Writing - review & editing Search for more papers by this author Lucía Zhu Lucía Zhu Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - original draft, Writing - review & editing Search for more papers by this author Diana Retana Diana Retana Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Validation, Investigation, Visualization, Methodology Search for more papers by this author Pedro García-Gómez Pedro García-Gómez orcid.org/0000-0003-0694-3942 Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Validation, Investigation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Laura Álvaro-Espinosa Laura Álvaro-Espinosa Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Investigation, Methodology Search for more papers by this author Neibla Priego Neibla Priego Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Investigation, Methodology Search for more papers by this author Mariam Masmudi-Martín Mariam Masmudi-Martín Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Investigation, Methodology Search for more papers by this author Natalia Yebra Natalia Yebra Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Formal analysis, Visualization, Methodology Search for more papers by this author Lauritz Miarka Lauritz Miarka Brain Metastasis Group, CNIO, Madrid, Spain Contribution: Data curation, Formal analysis, Validation, Writing - review & editing Search for more papers by this author Elena Hernández-Encinas Elena Hernández-Encinas Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Formal analysis, Methodology Search for more papers by this author Carmen Blanco-Aparicio Carmen Blanco-Aparicio Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Resources, Formal analysis, Validation, Investigation, Methodology Search for more papers by this author Sonia Martínez Sonia Martínez orcid.org/0000-0003-2230-7794 Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Formal analysis, Validation, Investigation, Visualization, Methodology Search for more papers by this author Cecilia Sobrino Cecilia Sobrino Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Investigation, Methodology Search for more papers by this author Nuria Ajenjo Nuria Ajenjo Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Resources, Project administration Search for more papers by this author Maria-Jesus Artiga Maria-Jesus Artiga orcid.org/0000-0003-0436-8497 Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Supervision, Project administration Search for more papers by this author Eva Ortega-Paino Eva Ortega-Paino Biobank, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Resources, Supervision, Project administration Search for more papers by this author Raúl Torres-Ruiz Raúl Torres-Ruiz orcid.org/0000-0001-9606-0398 Molecular Cytogenetics Unit, CNIO, Madrid, Spain Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Madrid, Spain Search for more papers by this author Sandra Rodríguez-Perales Sandra Rodríguez-Perales Molecular Cytogenetics Unit, CNIO, Madrid, Spain Contribution: Methodology Search for more papers by this author RENACER RENACER The list of additional RENACER members and their affiliations appears at the end of this article. Search for more papers by this author Riccardo Soffietti Riccardo Soffietti Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy Contribution: Resources, Writing - review & editing Search for more papers by this author Luca Bertero Luca Bertero orcid.org/0000-0001-9887-7668 Department of Medical Sciences, University of Turin, Turin, Italy Contribution: Formal analysis, Validation, Methodology Search for more papers by this author Paola Cassoni Paola Cassoni Department of Medical Sciences, University of Turin, Turin, Italy Contribution: Resources, Supervision Search for more papers by this author Tobias Weiss Tobias Weiss orcid.org/0000-0002-5533-9429 Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland Contribution: Resources, Formal analysis, Validation, Investigation, Methodology, Writing - review & editing Search for more papers by this author Javier Muñoz Javier Muñoz orcid.org/0000-0003-3288-3496 Proteomics Unit, ProteoRedISCIII, CNIO, Madrid, Spain Contribution: Resources, Formal analysis, Validation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Juan Manuel Sepúlveda Juan Manuel Sepúlveda Neuro-Oncology Unit, Hospital Universitario 12 de Octubre, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Search for more papers by this author Pedro González-León Pedro González-León Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Resources, Investigation, Methodology Search for more papers by this author Luis Jiménez-Roldán Luis Jiménez-Roldán Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Department of Surgery, Universidad Complutense de Madrid, Madrid, Spain Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Resources, Formal analysis, Investigation, Methodology Search for more papers by this author Luis Miguel Moreno Luis Miguel Moreno orcid.org/0000-0003-4963-7064 Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Search for more papers by this author Olga Esteban Olga Esteban Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Resources, Validation, Investigation, Methodology Search for more papers by this author Ángel Pérez-Núñez Ángel Pérez-Núñez orcid.org/0000-0002-2391-6586 Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain Department of Surgery, Universidad Complutense de Madrid, Madrid, Spain Neuro-Oncology Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Resources, Formal analysis, Supervision, Investigation, Visualization, Writing - review & editing Search for more papers by this author Aurelio Hernández-Laín Aurelio Hernández-Laín Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Data curation, Supervision, Validation, Investigation, Methodology, Writing - review & editing Search for more papers by this author Oscar Toldos Oscar Toldos Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Contribution: Validation, Methodology Search for more papers by this author Yolanda Ruano Yolanda Ruano Pathology Department, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain Universidad Francisco de Vitoria, Madrid, Spain Contribution: Methodology Search for more papers by this author Lucía Alcázar Lucía Alcázar Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain Search for more papers by this author Guillermo Blasco Guillermo Blasco Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain Search for more papers by this author José Fernández-Alén José Fernández-Alén Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Supervision, Project administration Search for more papers by this author Eduardo Caleiras Eduardo Caleiras Histopathology Unit, CNIO, Madrid, Spain Contribution: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology Search for more papers by this author Miguel Lafarga Miguel Lafarga orcid.org/0000-0003-3402-1152 Department of Anatomy and Cell Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of Cantabria-IDIVAL, Santander, Spain Contribution: Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Diego Megías Diego Megías Confocal Microscopy Unit, CNIO, Madrid, Spain Contribution: Validation, Investigation, Visualization, Methodology Search for more papers by this author Osvaldo Graña-Castro Osvaldo Graña-Castro Bioinformatics Unit, CNIO, Madrid, Spain Search for more papers by this author Carolina Nör Carolina Nör Developmental and Stem Cell Biology Program and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada Contribution: Resources, Supervision, Validation, Investigation, Methodology Search for more papers by this author Michael D Taylor Michael D Taylor Developmental and Stem Cell Biology Program and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada Search for more papers by this author Leonie S Young Leonie S Young Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland Contribution: Resources, Data curation, Supervision, Methodology Search for more papers by this author Damir Varešlija Damir Varešlija orcid.org/0000-0003-1000-0357 Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland Contribution: Data curation, Validation, Investigation, Visualization, Methodology, Writing - review & editing Search for more papers by this author Nicola Cosgrove Nicola Cosgrove Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland Contribution: Resources, Data curation, Methodology, Writing - review & editing Search for more papers by this author Fergus J Couch Fergus J Couch Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA Contribution: Resources, Data curation Search for more papers by this author Lorena Cussó Lorena Cussó Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain Unidad de Imagen Avanzada, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Contribution: Formal analysis, Methodology Search for more papers by this author Manuel Desco Manuel Desco Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain Unidad de Imagen Avanzada, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Contribution: Formal analysis, Supervision, Visualization, Methodology Search for more papers by this author Silvana Mouron Silvana Mouron Breast Cancer Clinical Research Unit, CNIO, Madrid, Spain Contribution: Data curation, Formal analysis, Visualization, Methodology, Writing - review & editing Search for more papers by this author Miguel Quintela-Fandino Miguel Quintela-Fandino Breast Cancer Clinical Research Unit, CNIO, Madrid, Spain Search for more papers by this author Michael Weller Michael Weller Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland Contribution: Supervision, Validation, Methodology Search for more papers by this author Joaquín Pastor Joaquín Pastor Experimental Therapeutics Programme, CNIO, Madrid, Spain Contribution: Resources, Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology Search for more papers by this author Manuel Valiente Corresponding Author Manuel Valiente [email protected] orcid.org/0000-0002-0647-7542 Brain Metastasis Group, CNIO, Madrid, Spain The list of additional RENACER members and their affiliations appears at the end of this article. Contribution: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing - original draft, Project administration, Writing - review & editing Search for more papers by this author Author Information Lucía Zhu1, Diana Retana1, Pedro García-Gómez1, Laura Álvaro-Espinosa1, Neibla Priego1, Mariam Masmudi-Martín1, Natalia Yebra1, Lauritz Miarka1, Elena Hernández-Encinas2, Carmen Blanco-Aparicio2, Sonia Martínez2, Cecilia Sobrino3, Nuria Ajenjo3, Maria-Jesus Artiga3, Eva Ortega-Paino3, Raúl Torres-Ruiz4,5, Sandra Rodríguez-Perales4, , Riccardo Soffietti6, Luca Bertero7, Paola Cassoni7, Tobias Weiss8, Javier Muñoz9,30,31, Juan Manuel Sepúlveda10, Pedro González-León11, Luis Jiménez-Roldán11,12,13, Luis Miguel Moreno11, Olga Esteban11, Ángel Pérez-Núñez11,12,14, Aurelio Hernández-Laín13, Oscar Toldos13, Yolanda Ruano15,16, Lucía Alcázar17, Guillermo Blasco17, José Fernández-Alén17, Eduardo Caleiras18, Miguel Lafarga19, Diego Megías20, Osvaldo Graña-Castro21, Carolina Nör22, Michael D Taylor22, Leonie S Young23, Damir Varešlija23, Nicola Cosgrove23, Fergus J Couch24, Lorena Cussó25,26,27,28, Manuel Desco25,26,27,28, Silvana Mouron29, Miguel Quintela-Fandino29, Michael Weller8, Joaquín Pastor2, Manuel Valiente *,1, Adolfo de la Lama-Zaragoza, Lourdes Calero-Felix, Concepcion Fiaño-Valverde, Pedro David Delgado-López, Antonio Montalvo-Afonso, Mar Pascual-Llorente, Ángela Díaz-Piqueras, SH Nam-Cha, Cristina Barrena López, Gerard Plans Ahicart, Elena Martínez-Saez, Santiago Ramón y Cajal and Pilar Nicolás 1Brain Metastasis Group, CNIO, Madrid, Spain 2Experimental Therapeutics Programme, CNIO, Madrid, Spain 3Biobank, CNIO, Madrid, Spain 4Molecular Cytogenetics Unit, CNIO, Madrid, Spain 5Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Madrid, Spain 6Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy 7Department of Medical Sciences, University of Turin, Turin, Italy 8Department of Neurology, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland 9Proteomics Unit, ProteoRedISCIII, CNIO, Madrid, Spain 10Neuro-Oncology Unit, Hospital Universitario 12 de Octubre, Madrid, Spain 11Neurosurgery Unit, Hospital Universitario 12 de Octubre, Madrid, Spain 12Department of Surgery, Universidad Complutense de Madrid, Madrid, Spain 13Neuropathology Unit, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain 14Neuro-Oncology Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain 15Pathology Department, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain 16Universidad Francisco de Vitoria, Madrid, Spain 17Neurosurgery Department, Hospital Universitario de La Princesa, Madrid, Spain 18Histopathology Unit, CNIO, Madrid, Spain 19Department of Anatomy and Cell Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of Cantabria-IDIVAL, Santander, Spain 20Confocal Microscopy Unit, CNIO, Madrid, Spain 21Bioinformatics Unit, CNIO, Madrid, Spain 22Developmental and Stem Cell Biology Program and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada 23Endocrine Oncology Research Group, Department of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland 24Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA 25Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain 26Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain 27Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain 28Unidad de
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