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Cutaneous reactions to COVID-19 vaccines: A review

2022; Elsevier BV; Volume: 7; Linguagem: Inglês

10.1016/j.jdin.2022.01.011

2666-3287

See Wei Tan, Yew Chong Tam, Shiu Ming Pang,

Heparin-Induced Thrombocytopenia and Thrombosis

The increasing number of reports on cutaneous reactions following COVID-19 vaccination has led to growing concerns among certain groups.We reviewed the published reports of cutaneous lesions after COVID-19 vaccination.We conducted a literature search for original and review articles published between January 1, 2020, and September 27, 2021.Eleven cutaneous reactions associated with COVID-19 vaccines were determined; the most prevalent reactions were local injection site reactions, delayed local reactions, urticaria, angioedema, and morbilliform eruptions. There were more reports on skin reactions following the administration of messenger RNA-based vaccines than on those following the administration of adenoviral vector or inactivated whole-virus vaccines, in part, due to their higher administration rate. Most reported skin reactions occurred after the first vaccine dose.A reporting bias could not be excluded, and skin biopsy results were not available for most included individuals. Moreover, given that the included trials focused on vaccine efficacy, there was a lack of details concerning cutaneous reactions and participant information.Not all cutaneous reactions observed after COVID-19 vaccination are hypersensitivity reactions. Different cutaneous reactions may reflect underlying immune responses to the vaccines. A large majority of COVID-19 vaccination reactions were mild and self-limiting, and people should be encouraged to complete their vaccination regimen.