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T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

2022; Nature Portfolio; Volume: 13; Issue: 1 Linguagem: Inglês

10.1038/s41467-022-28523-1

2041-1723

Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiß, Daniel Delev, Julius M. Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Jürgen Beck, Henrike Salié, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland,

Neuroinflammation and Neurodegeneration Mechanisms

Despite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-10-releasing HMOX1