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Dupilumab for the treatment of atopic dermatitis: real-world data from the Czech Republic BIOREP registry

2022; Informa; Volume: 33; Issue: 5 Linguagem: Inglês

10.1080/09546634.2022.2043545

1471-1753

Martina Kojanová, Milena Tanczosová, Daniela Štrosová, Petra Cetkovská, Jorga Fialová, Tomáš Doležal, Alena Machovcová, Spyridon Gkalpakiotis,

Asthma and respiratory diseases

Dupilumab has been approved to treat moderate-to-severe atopic dermatitis; however, the data in a real-world setting are still limited.To analyze the effectiveness and safety of dupilumab.This was a real-life Czech multicenter retrospective study from patients treated with dupilumab for severe AD.A total of 360 patients were included. At 16 weeks, 66.6, 34.1, and 5.5% of patients achieved EASI75/90 and EASI100, respectively. Improvement continued with the time, and the proportion of patients with EASI75/90 and EASI100 increased to 89.5, 55.6, and 12.9% after one year of treatment and reached 95.8, 60.4, and 27.1% in the second year of therapy, respectively. A significant reduction was observed in the DLQI scores. The most common adverse events were infections in 5.8% of patients, followed by ocular complications in 2.5% of patients. Persistence rates were 98.2% at four months to 93.1% at month 24, and lack of effectiveness was the most common reason for discontinuation.This real-life study confirmed the effectiveness and safety of dupilumab in a real-life setting during the COVID-19 pandemic. Our study revealed a higher frequency of infections and a lower conjunctivitis frequency than other real-life studies and clinical trials.