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Erythrocytes Induce Vascular Dysfunction in COVID-19

2022; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês

10.1016/j.jacbts.2021.12.003

2452-302X

Ali Mahdi, Aida Collado, John Tengbom, Tong Jiao, Tigist Wodaje, Niclas Johansson, Filip Farnebo, Anna Färnert, Jiangning Yang, Jon O. Lundberg, Zhichao Zhou, John Pernow,

Long-Term Effects of COVID-19

Current knowledge regarding mechanisms underlying cardiovascular complications in patients with COVID-19 is limited and urgently needed. We shed light on a previously unrecognized mechanism and unravel a key role of red blood cells, driving vascular dysfunction in patients with COVID-19 infection. We establish the presence of profound and persistent endothelial dysfunction in vivo in patients with COVID-19. Mechanistically, we show that targeting reactive oxygen species or arginase 1 improves vascular dysfunction mediated by red blood cells. These translational observations hold promise that restoring the redox balance in red blood cells might alleviate the clinical complications of COVID-19-associated vascular dysfunction.