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Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu Infection

2022; Oxford University Press; Volume: 226; Issue: 7 Linguagem: Inglês

10.1093/infdis/jiac053

1537-6613

Keiya Uriu, Paúl Cárdenas, Érika Muñoz, Verónica Barragán, Yusuke Kosugi, Kotaro Shirakawa, Akifumi Takaori‐Kondo, Jumpei Ito, Daichi Yamasoba, Izumi Kimura, Mai Suganami, Akiko Oide, Miyabishara Yokoyama, Mika Chiba, So Nakagawa, Jiaqi Wu, Miyoko Takahashi, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Kayoko Nagata, Yohei Yanagida, Yugo Kawai, Yusuke Tashiro, Atsushi Kaneda, Taka‐aki Nakada, M. Seki, Ryoji Fujiki, Tadanaga Shimada, Kiyoshi Hirahara, Koutaro Yokote, Toshinori Nakayama, Takashi Irie, Ryoko Kawabata, Nanami Morizako, Takasuke Fukuhara, Kenta Shimizu, Kana Tsushima, Haruko Kubo, Terumasa Ikeda, Chihiro Motozono, Hesham Nasser, Ryo Shimizu, Yue Yuan, Kazuko Kitazato, Haruyo Hasebe, Takamasa Ueno, Akatsuki Saito, Erika P. Butlertanaka, Yuri Tanaka, Kenzo Tokunaga, Seiya Ozono, Kenji Sadamasu, Hiroyuki Asakura, Isao Yoshida, Mami Nagashima, Kazuhisa Yoshimura, Sully Márquez, Belén Prado-Vivar, Mónica Becerra-Wong, Mateo Carvajal, Gabriel Trueba, Patricio Rojas‐Silva, Michelle Grunauer, Bernardo Gutiérrez, Juan José Guadalupe, Juan Carlos Fernández‐Cadena, Derly Andrade-Molina, Manuel E. Baldeón, Andrea Pinos, Kei Sato,

COVID-19 Clinical Research Studies

We have recently revealed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mu variant shows a pronounced resistance to antibodies elicited by natural SARS-CoV-2 infection and vaccination.However, it remains unclear which mutations determine the resistance of SARS-CoV-2 Mu to antiviral sera. In addition, it is unclear how SARS-CoV-2 Mu infection induces antiviral immunity.In this study, we reveal that the 2 mutations in the SARS-CoV-2 Mu spike protein, YY144-145TSN and E484K, are responsible for the resistance to coronavirus disease 2019 convalescent sera during early 2020 and vaccine sera.It is notable that the convalescent sera of SARS-CoV-2 Mu-infected individuals are broadly antiviral against Mu as well as other SARS-CoV-2 variants of concern and interest.