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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

2022; Cell Press; Volume: 40; Issue: 4 Linguagem: Inglês

10.1016/j.ccell.2022.02.003

ISSN

1878-3686

Autores

Peng Liao, Weimin Wang, Weichao Wang, Ilona Kryczek, Li Xiong, Yingjie Bian, Amanda Sell, Shuang Wei, Sara Grove, Jeffrey Johnson, Paul D. Kennedy, Miguel A. Gijón, Yatrik M. Shah, Weiping Zou,

Tópico(s)

Cancer-related molecular mechanisms research

Resumo

Tumor cell intrinsic ferroptosis-initiating mechanisms are unknown. Here, we discover that T cell-derived interferon (IFN)γ in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mode of action for CD8

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