Extended Spectrum Beta-lactamases: Definition, Classification and Epidemiology
2015; Caister Academic Press; Linguagem: Inglês
10.21775/cimb.017.011
ISSN1467-3045
AutoresSobhan Ghafourian, Nourkhoda Sadeghifard, Sara Soheili, Zamberi Sekawi,
Tópico(s)Vibrio bacteria research studies
ResumoExtended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin.They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyiminomonobactam.The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL producing organisms which are among those responsible for antibiotic resistant strains.Globally, ESBLs are considered to be problematic, particularly in hospitalized patients.There is an increasing frequency of ESBL in different parts of the world.The high risk patients are those contaminated with ESBL producer strains as it renders treatment to be ineffective in these patients.Thus, there an immediate needs to identify EBSL and formulate strategic policy initiatives to reduce their prevalence. Classification of beta-lactamasesThere is a different scheme for classification of betalactamases, the most famous was developed by Bush, Jacoby and Medeiros (Bush et al., 1995).This scheme is
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